Role of human major histocompatibility complex DQ molecules in superantigenicity of streptococcus-derived protein

Y. Esaki, Y. Fukui, T. Sudo, K. Yamamoto, T. Inamitsu, Y. Nishimura, K. Hirokawa, A. Kimura, T. Sasazuki

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Abstract

Antigenicity of peptic extract from type 12 group A streptococci (PEAST12) for T cells was examined in major histocompatibility complex (MHC) class II transgenic mice. PEAST12 was mitogenic for murine T cells when antigen- presenting cells were obtained from human MHC (HLA)-DQ4αβ transgenic mice or from DQ6αβ transgenic mice but was not mitogenic in DRα transgenic, DR51αβ transgenic, Eα transgenic, or nontransgenic mice. In addition, PEAST12 showed mitogenicity for murine T cells in DQ4α singly transgenic mice but not in DQ4β singly transgenic mice. T-cell stimulation by PEAST12 was unrestricted by but dependent on the expression of HLA-DQ molecules on antigen-presenting cells, and PEAST12 selectively activated T-cell receptor Vβ11-, Vβ15-, and Vβ18-positive T cells in mice. We propose that PEAST12 contains a superantigen which binds preferentially to the α-chain of HLA-DQ molecules. The well-known phenomenon that peptic extracts from group A streptococci are mitogenic in humans but not in mice is likely due to structural differences in MHC class II molecules between these two species of mammals.

Original languageEnglish
Pages (from-to)1228-1235
Number of pages8
JournalInfection and Immunity
Volume62
Issue number4
Publication statusPublished - Jan 1 1994

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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    Esaki, Y., Fukui, Y., Sudo, T., Yamamoto, K., Inamitsu, T., Nishimura, Y., Hirokawa, K., Kimura, A., & Sasazuki, T. (1994). Role of human major histocompatibility complex DQ molecules in superantigenicity of streptococcus-derived protein. Infection and Immunity, 62(4), 1228-1235.