Role of hypertension, dyslipidemia and diabetes mellitus in the development of coronary atherosclerosis in Japan

M. Washio, S. Sasazuki, H. Kodama, K. Yoshimasu, Y. Liu, K. Tanaka, Shoji Tokunaga, S. Kono, H. Arai, S. Koyanagi, K. Hiyamuta, Y. Doi, T. Kawano, O. Nakagaki, K. Takada, T. Nii, K. Shirai, M. Ideishi, K. Arakawa, M. Mohri & 1 others A. Takeshita

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The present study evaluated the effect of hypertension (HT), dyslipidemia and diabetes mellitus (DM) on the development of coronary atherosclerosis in the Japanese population, using a cross-sectional study of 433 patients (254 men and 179 women) aged 30 years or older who underwent coronary angiography for suspected or known coronary heart disease angina at 5 cardiology departments in the Fukuoka area between September 1996 and August 1997. Patients with a disease duration of 6 months or more were excluded. The main outcome measure was angiographically defined coronary artery stenosis and was found to a significant degree in 146 patients (33.7%). HT, DM, low levels of high-density lipoprotein cholesterol (HDL-C) and hypertriglyceridemia remained as significant coronary artery disease (CAD) risk factors even after controlling for age, sex, hospital, smoking, alcohol use, body mass index and leisure time physical activity. However, hypercholesterolemia was not a significant risk factor after adjusting for these variables. After controlling for these variables, DM, low HDL-C and hypertriglyceridemia were significant CAD risk factors for men, but only DM was a significant CAD risk factor in women. These results indicate that in Japan DM, low HDL-C and hypertriglyceridemia may be more important CAD risk factors than hypercholesterolemia.

Original languageEnglish
Pages (from-to)731-737
Number of pages7
JournalJAPANESE CIRCULATION JOURNAL
Volume65
Issue number8
DOIs
Publication statusPublished - Aug 23 2001

Fingerprint

Dyslipidemias
Coronary Artery Disease
Diabetes Mellitus
Japan
Hypertriglyceridemia
Hypertension
HDL Cholesterol
Hypercholesterolemia
LDL Cholesterol
Coronary Stenosis
Leisure Activities
Cardiology
Coronary Angiography
Coronary Disease
Body Mass Index
Cross-Sectional Studies
Smoking
Alcohols
Outcome Assessment (Health Care)
Exercise

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Washio, M., Sasazuki, S., Kodama, H., Yoshimasu, K., Liu, Y., Tanaka, K., ... Takeshita, A. (2001). Role of hypertension, dyslipidemia and diabetes mellitus in the development of coronary atherosclerosis in Japan. JAPANESE CIRCULATION JOURNAL, 65(8), 731-737. https://doi.org/10.1253/jcj.65.731

Role of hypertension, dyslipidemia and diabetes mellitus in the development of coronary atherosclerosis in Japan. / Washio, M.; Sasazuki, S.; Kodama, H.; Yoshimasu, K.; Liu, Y.; Tanaka, K.; Tokunaga, Shoji; Kono, S.; Arai, H.; Koyanagi, S.; Hiyamuta, K.; Doi, Y.; Kawano, T.; Nakagaki, O.; Takada, K.; Nii, T.; Shirai, K.; Ideishi, M.; Arakawa, K.; Mohri, M.; Takeshita, A.

In: JAPANESE CIRCULATION JOURNAL, Vol. 65, No. 8, 23.08.2001, p. 731-737.

Research output: Contribution to journalArticle

Washio, M, Sasazuki, S, Kodama, H, Yoshimasu, K, Liu, Y, Tanaka, K, Tokunaga, S, Kono, S, Arai, H, Koyanagi, S, Hiyamuta, K, Doi, Y, Kawano, T, Nakagaki, O, Takada, K, Nii, T, Shirai, K, Ideishi, M, Arakawa, K, Mohri, M & Takeshita, A 2001, 'Role of hypertension, dyslipidemia and diabetes mellitus in the development of coronary atherosclerosis in Japan', JAPANESE CIRCULATION JOURNAL, vol. 65, no. 8, pp. 731-737. https://doi.org/10.1253/jcj.65.731
Washio, M. ; Sasazuki, S. ; Kodama, H. ; Yoshimasu, K. ; Liu, Y. ; Tanaka, K. ; Tokunaga, Shoji ; Kono, S. ; Arai, H. ; Koyanagi, S. ; Hiyamuta, K. ; Doi, Y. ; Kawano, T. ; Nakagaki, O. ; Takada, K. ; Nii, T. ; Shirai, K. ; Ideishi, M. ; Arakawa, K. ; Mohri, M. ; Takeshita, A. / Role of hypertension, dyslipidemia and diabetes mellitus in the development of coronary atherosclerosis in Japan. In: JAPANESE CIRCULATION JOURNAL. 2001 ; Vol. 65, No. 8. pp. 731-737.
@article{2f99f669682f439996b07999624b72d6,
title = "Role of hypertension, dyslipidemia and diabetes mellitus in the development of coronary atherosclerosis in Japan",
abstract = "The present study evaluated the effect of hypertension (HT), dyslipidemia and diabetes mellitus (DM) on the development of coronary atherosclerosis in the Japanese population, using a cross-sectional study of 433 patients (254 men and 179 women) aged 30 years or older who underwent coronary angiography for suspected or known coronary heart disease angina at 5 cardiology departments in the Fukuoka area between September 1996 and August 1997. Patients with a disease duration of 6 months or more were excluded. The main outcome measure was angiographically defined coronary artery stenosis and was found to a significant degree in 146 patients (33.7{\%}). HT, DM, low levels of high-density lipoprotein cholesterol (HDL-C) and hypertriglyceridemia remained as significant coronary artery disease (CAD) risk factors even after controlling for age, sex, hospital, smoking, alcohol use, body mass index and leisure time physical activity. However, hypercholesterolemia was not a significant risk factor after adjusting for these variables. After controlling for these variables, DM, low HDL-C and hypertriglyceridemia were significant CAD risk factors for men, but only DM was a significant CAD risk factor in women. These results indicate that in Japan DM, low HDL-C and hypertriglyceridemia may be more important CAD risk factors than hypercholesterolemia.",
author = "M. Washio and S. Sasazuki and H. Kodama and K. Yoshimasu and Y. Liu and K. Tanaka and Shoji Tokunaga and S. Kono and H. Arai and S. Koyanagi and K. Hiyamuta and Y. Doi and T. Kawano and O. Nakagaki and K. Takada and T. Nii and K. Shirai and M. Ideishi and K. Arakawa and M. Mohri and A. Takeshita",
year = "2001",
month = "8",
day = "23",
doi = "10.1253/jcj.65.731",
language = "English",
volume = "65",
pages = "731--737",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "8",

}

TY - JOUR

T1 - Role of hypertension, dyslipidemia and diabetes mellitus in the development of coronary atherosclerosis in Japan

AU - Washio, M.

AU - Sasazuki, S.

AU - Kodama, H.

AU - Yoshimasu, K.

AU - Liu, Y.

AU - Tanaka, K.

AU - Tokunaga, Shoji

AU - Kono, S.

AU - Arai, H.

AU - Koyanagi, S.

AU - Hiyamuta, K.

AU - Doi, Y.

AU - Kawano, T.

AU - Nakagaki, O.

AU - Takada, K.

AU - Nii, T.

AU - Shirai, K.

AU - Ideishi, M.

AU - Arakawa, K.

AU - Mohri, M.

AU - Takeshita, A.

PY - 2001/8/23

Y1 - 2001/8/23

N2 - The present study evaluated the effect of hypertension (HT), dyslipidemia and diabetes mellitus (DM) on the development of coronary atherosclerosis in the Japanese population, using a cross-sectional study of 433 patients (254 men and 179 women) aged 30 years or older who underwent coronary angiography for suspected or known coronary heart disease angina at 5 cardiology departments in the Fukuoka area between September 1996 and August 1997. Patients with a disease duration of 6 months or more were excluded. The main outcome measure was angiographically defined coronary artery stenosis and was found to a significant degree in 146 patients (33.7%). HT, DM, low levels of high-density lipoprotein cholesterol (HDL-C) and hypertriglyceridemia remained as significant coronary artery disease (CAD) risk factors even after controlling for age, sex, hospital, smoking, alcohol use, body mass index and leisure time physical activity. However, hypercholesterolemia was not a significant risk factor after adjusting for these variables. After controlling for these variables, DM, low HDL-C and hypertriglyceridemia were significant CAD risk factors for men, but only DM was a significant CAD risk factor in women. These results indicate that in Japan DM, low HDL-C and hypertriglyceridemia may be more important CAD risk factors than hypercholesterolemia.

AB - The present study evaluated the effect of hypertension (HT), dyslipidemia and diabetes mellitus (DM) on the development of coronary atherosclerosis in the Japanese population, using a cross-sectional study of 433 patients (254 men and 179 women) aged 30 years or older who underwent coronary angiography for suspected or known coronary heart disease angina at 5 cardiology departments in the Fukuoka area between September 1996 and August 1997. Patients with a disease duration of 6 months or more were excluded. The main outcome measure was angiographically defined coronary artery stenosis and was found to a significant degree in 146 patients (33.7%). HT, DM, low levels of high-density lipoprotein cholesterol (HDL-C) and hypertriglyceridemia remained as significant coronary artery disease (CAD) risk factors even after controlling for age, sex, hospital, smoking, alcohol use, body mass index and leisure time physical activity. However, hypercholesterolemia was not a significant risk factor after adjusting for these variables. After controlling for these variables, DM, low HDL-C and hypertriglyceridemia were significant CAD risk factors for men, but only DM was a significant CAD risk factor in women. These results indicate that in Japan DM, low HDL-C and hypertriglyceridemia may be more important CAD risk factors than hypercholesterolemia.

UR - http://www.scopus.com/inward/record.url?scp=0034879398&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034879398&partnerID=8YFLogxK

U2 - 10.1253/jcj.65.731

DO - 10.1253/jcj.65.731

M3 - Article

VL - 65

SP - 731

EP - 737

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 8

ER -