Role of kinin and prostaglandin in cutaneous thermal nociception

Shigeyuki Matsuzaki, Izumi Hayashi, Yoshihiro Nara, Kazuhisa Kamata, Mariko Yamanaka, Hirotsugu Okamoto, Sumio Hoka, Masataka Majima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Involvements of kinin and prostaglandin and their interaction in noxious thermal stimuli were investigated in noninflamed and inflamed rats. The nociceptive response was evaluated from the escape latency of foot withdrawal to the thermal stimuli with a beam of light. The escape latency in kininogens-deficient Brown Norway (B/N-) Katholiek rats was significantly longer than that in the normal strain, B/N-Kitasato rats. The latency in B/N-Kitasato rat was prolonged by administration of a bradykinin (BK) B2 receptor antagonist, FR173657 (30 mg/kg, p.o.), whereas it was shortened by pretreatment with a kininase II inhibitor, captopril (10 mg/kg, i.p.). Both agents did not affect the latency in B/N-Katholiek rats. In normal Sprague-Dawley (SD) rat, administration of indomethacin did not change the escape latency against the thermal stimuli. In contrast, administration of indomethacin or a relatively cyclooxygenase-1-selective inhibitor, mofezolac (10 mg/kg, p.o.) significantly reduced numbers of writhing reaction in mice induced by acetic acid solution. Injection of lipopolysaccharide (1 mg/kg, i.v.) resulted in shortening escape latency at 8 h after the injection in B/N-Kitasato rats. This hyperalgesia could be reversed by pretreatment of the rats with indomethacin, a cyclooxygenase-2-selective inhibitor JTE-522 (10 mg/kg, p.o.), or FR173657, but not with mofezolac. The hyperalgesia was not seen in B/N-Katholiek rats. These results indicate that kinin has major participation in peripheral skin thermal nociception under noninflamed condition, although cyclooxygenases may have little participation. Prostaglandins produced by cyclooxygenase-2 could coordinate with BK to elicit hyperalgesia during inflammation induced by lipopolysaccharide.

Original languageEnglish
Pages (from-to)2005-2012
Number of pages8
JournalInternational Immunopharmacology
Volume2
Issue number13-14
DOIs
Publication statusPublished - Dec 1 2002

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Fingerprint Dive into the research topics of 'Role of kinin and prostaglandin in cutaneous thermal nociception'. Together they form a unique fingerprint.

  • Cite this

    Matsuzaki, S., Hayashi, I., Nara, Y., Kamata, K., Yamanaka, M., Okamoto, H., Hoka, S., & Majima, M. (2002). Role of kinin and prostaglandin in cutaneous thermal nociception. International Immunopharmacology, 2(13-14), 2005-2012. https://doi.org/10.1016/S1567-5769(02)00187-X