Role of leptin in pregnancy - A review

N. Sagawa, S. Yura, H. Itoh, H. Mise, K. Kakui, D. Korita, M. Takemura, M. A. Nuamah, Y. Ogawa, H. Masuzaki, K. Nakao, S. Fujii

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Leptin is an adipocyte-derived hormone that decreases food intake and body weight via its receptor in the hypothalamus. In rodents, it also modulates glucose metabolism by increasing insulin sensitivity. We previously reported that leptin is produced by human placental trophoblasts. We also revealed that leptin gene expression in the placenta was augmented in severe pre-eclampsia, and suggested that placental hypoxia may play a role in this augmentation. Maternal plasma leptin levels correlated well with mean blood pressure, but not with body mass index. Plasma leptin levels in pre-eclamptic women with IUGR were higher than those without IUGR (P<0.05). We further examined the effects of hyperleptinemia on the course of pregnancy by using transgenic mice (Tg) overexpressing leptin. In pregnant Tg mice, food intake was significantly less than non-Tg, and the fetal body weights were reduced to approximately 70 per cent of those of non-Tg. Resistin is a novel adipocyte-derived hormone that decreases insulin sensitivity and increases plasma glucose concentration, thus contributing the development of obesity-related type II diabetes mellitus. We recently found that resistin gene is expressed in the human placenta as well as adipose tissue. In this review, possible roles of placental leptin and resistin are discussed.

Original languageEnglish
JournalPlacenta
Volume23
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jan 1 2002
Externally publishedYes

Fingerprint

Leptin
Pregnancy
Resistin
Fetal Growth Retardation
Adipocytes
Placenta
Insulin Resistance
Eating
Hormones
Glucose
Fetal Weight
Trophoblasts
Pre-Eclampsia
Type 2 Diabetes Mellitus
Transgenic Mice
Hypothalamus
Adipose Tissue
Rodentia
Body Mass Index
Obesity

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Developmental Biology

Cite this

Sagawa, N., Yura, S., Itoh, H., Mise, H., Kakui, K., Korita, D., ... Fujii, S. (2002). Role of leptin in pregnancy - A review. Placenta, 23(SUPPL. 1). https://doi.org/10.1053/plac.2002.0814

Role of leptin in pregnancy - A review. / Sagawa, N.; Yura, S.; Itoh, H.; Mise, H.; Kakui, K.; Korita, D.; Takemura, M.; Nuamah, M. A.; Ogawa, Y.; Masuzaki, H.; Nakao, K.; Fujii, S.

In: Placenta, Vol. 23, No. SUPPL. 1, 01.01.2002.

Research output: Contribution to journalArticle

Sagawa, N, Yura, S, Itoh, H, Mise, H, Kakui, K, Korita, D, Takemura, M, Nuamah, MA, Ogawa, Y, Masuzaki, H, Nakao, K & Fujii, S 2002, 'Role of leptin in pregnancy - A review', Placenta, vol. 23, no. SUPPL. 1. https://doi.org/10.1053/plac.2002.0814
Sagawa N, Yura S, Itoh H, Mise H, Kakui K, Korita D et al. Role of leptin in pregnancy - A review. Placenta. 2002 Jan 1;23(SUPPL. 1). https://doi.org/10.1053/plac.2002.0814
Sagawa, N. ; Yura, S. ; Itoh, H. ; Mise, H. ; Kakui, K. ; Korita, D. ; Takemura, M. ; Nuamah, M. A. ; Ogawa, Y. ; Masuzaki, H. ; Nakao, K. ; Fujii, S. / Role of leptin in pregnancy - A review. In: Placenta. 2002 ; Vol. 23, No. SUPPL. 1.
@article{6a3a482c25c949f59d4bef027ed9cbea,
title = "Role of leptin in pregnancy - A review",
abstract = "Leptin is an adipocyte-derived hormone that decreases food intake and body weight via its receptor in the hypothalamus. In rodents, it also modulates glucose metabolism by increasing insulin sensitivity. We previously reported that leptin is produced by human placental trophoblasts. We also revealed that leptin gene expression in the placenta was augmented in severe pre-eclampsia, and suggested that placental hypoxia may play a role in this augmentation. Maternal plasma leptin levels correlated well with mean blood pressure, but not with body mass index. Plasma leptin levels in pre-eclamptic women with IUGR were higher than those without IUGR (P<0.05). We further examined the effects of hyperleptinemia on the course of pregnancy by using transgenic mice (Tg) overexpressing leptin. In pregnant Tg mice, food intake was significantly less than non-Tg, and the fetal body weights were reduced to approximately 70 per cent of those of non-Tg. Resistin is a novel adipocyte-derived hormone that decreases insulin sensitivity and increases plasma glucose concentration, thus contributing the development of obesity-related type II diabetes mellitus. We recently found that resistin gene is expressed in the human placenta as well as adipose tissue. In this review, possible roles of placental leptin and resistin are discussed.",
author = "N. Sagawa and S. Yura and H. Itoh and H. Mise and K. Kakui and D. Korita and M. Takemura and Nuamah, {M. A.} and Y. Ogawa and H. Masuzaki and K. Nakao and S. Fujii",
year = "2002",
month = "1",
day = "1",
doi = "10.1053/plac.2002.0814",
language = "English",
volume = "23",
journal = "Placenta",
issn = "0143-4004",
publisher = "W.B. Saunders Ltd",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Role of leptin in pregnancy - A review

AU - Sagawa, N.

AU - Yura, S.

AU - Itoh, H.

AU - Mise, H.

AU - Kakui, K.

AU - Korita, D.

AU - Takemura, M.

AU - Nuamah, M. A.

AU - Ogawa, Y.

AU - Masuzaki, H.

AU - Nakao, K.

AU - Fujii, S.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Leptin is an adipocyte-derived hormone that decreases food intake and body weight via its receptor in the hypothalamus. In rodents, it also modulates glucose metabolism by increasing insulin sensitivity. We previously reported that leptin is produced by human placental trophoblasts. We also revealed that leptin gene expression in the placenta was augmented in severe pre-eclampsia, and suggested that placental hypoxia may play a role in this augmentation. Maternal plasma leptin levels correlated well with mean blood pressure, but not with body mass index. Plasma leptin levels in pre-eclamptic women with IUGR were higher than those without IUGR (P<0.05). We further examined the effects of hyperleptinemia on the course of pregnancy by using transgenic mice (Tg) overexpressing leptin. In pregnant Tg mice, food intake was significantly less than non-Tg, and the fetal body weights were reduced to approximately 70 per cent of those of non-Tg. Resistin is a novel adipocyte-derived hormone that decreases insulin sensitivity and increases plasma glucose concentration, thus contributing the development of obesity-related type II diabetes mellitus. We recently found that resistin gene is expressed in the human placenta as well as adipose tissue. In this review, possible roles of placental leptin and resistin are discussed.

AB - Leptin is an adipocyte-derived hormone that decreases food intake and body weight via its receptor in the hypothalamus. In rodents, it also modulates glucose metabolism by increasing insulin sensitivity. We previously reported that leptin is produced by human placental trophoblasts. We also revealed that leptin gene expression in the placenta was augmented in severe pre-eclampsia, and suggested that placental hypoxia may play a role in this augmentation. Maternal plasma leptin levels correlated well with mean blood pressure, but not with body mass index. Plasma leptin levels in pre-eclamptic women with IUGR were higher than those without IUGR (P<0.05). We further examined the effects of hyperleptinemia on the course of pregnancy by using transgenic mice (Tg) overexpressing leptin. In pregnant Tg mice, food intake was significantly less than non-Tg, and the fetal body weights were reduced to approximately 70 per cent of those of non-Tg. Resistin is a novel adipocyte-derived hormone that decreases insulin sensitivity and increases plasma glucose concentration, thus contributing the development of obesity-related type II diabetes mellitus. We recently found that resistin gene is expressed in the human placenta as well as adipose tissue. In this review, possible roles of placental leptin and resistin are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0001820949&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0001820949&partnerID=8YFLogxK

U2 - 10.1053/plac.2002.0814

DO - 10.1053/plac.2002.0814

M3 - Article

C2 - 11978063

AN - SCOPUS:0001820949

VL - 23

JO - Placenta

JF - Placenta

SN - 0143-4004

IS - SUPPL. 1

ER -