Role of LRF/Pokemon in lineage fate decisions

Andrea Lunardi, Jlenia Guarnerio, Guocan Wang, Takahiro Maeda, Pier Paolo Pandolfi

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

In the human genome, 43 different genes are found that encode proteins belonging to the family of the POK (poxvirus and zinc finger and Krüppel)/ZBTB (zinc finger and broad complex, tramtrack, and bric à brac) factors. Generally considered transcriptional repressors, several of these genes play fundamental roles in cell lineage fate decision in various tissues, programming specific tasks throughout the life of the organism. Here, we focus on functions of leukemia/lymphoma-related factor/POK erythroid myeloid ontogenic factor, which is probably one of the most exciting and yet enigmatic members of the POK/ZBTB family.

Original languageEnglish
Pages (from-to)2845-2853
Number of pages9
JournalBlood
Volume121
Issue number15
DOIs
Publication statusPublished - Apr 11 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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  • Cite this

    Lunardi, A., Guarnerio, J., Wang, G., Maeda, T., & Pandolfi, P. P. (2013). Role of LRF/Pokemon in lineage fate decisions. Blood, 121(15), 2845-2853. https://doi.org/10.1182/blood-2012-11-292037