Role of LRF/Pokemon in lineage fate decisions

Andrea Lunardi, Jlenia Guarnerio, Guocan Wang, Takahiro Maeda, Pier Paolo Pandolfi

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

In the human genome, 43 different genes are found that encode proteins belonging to the family of the POK (poxvirus and zinc finger and Krüppel)/ZBTB (zinc finger and broad complex, tramtrack, and bric à brac) factors. Generally considered transcriptional repressors, several of these genes play fundamental roles in cell lineage fate decision in various tissues, programming specific tasks throughout the life of the organism. Here, we focus on functions of leukemia/lymphoma-related factor/POK erythroid myeloid ontogenic factor, which is probably one of the most exciting and yet enigmatic members of the POK/ZBTB family.

Original languageEnglish
Pages (from-to)2845-2853
Number of pages9
JournalBlood
Volume121
Issue number15
DOIs
Publication statusPublished - Apr 11 2013

Fingerprint

Zinc Fingers
Genes
Poxviridae
Zinc
Cell Lineage
Human Genome
Lymphoma
Leukemia
Tissue
Proteins

All Science Journal Classification (ASJC) codes

  • Immunology
  • Biochemistry
  • Hematology
  • Cell Biology

Cite this

Lunardi, A., Guarnerio, J., Wang, G., Maeda, T., & Pandolfi, P. P. (2013). Role of LRF/Pokemon in lineage fate decisions. Blood, 121(15), 2845-2853. https://doi.org/10.1182/blood-2012-11-292037

Role of LRF/Pokemon in lineage fate decisions. / Lunardi, Andrea; Guarnerio, Jlenia; Wang, Guocan; Maeda, Takahiro; Pandolfi, Pier Paolo.

In: Blood, Vol. 121, No. 15, 11.04.2013, p. 2845-2853.

Research output: Contribution to journalReview article

Lunardi, A, Guarnerio, J, Wang, G, Maeda, T & Pandolfi, PP 2013, 'Role of LRF/Pokemon in lineage fate decisions', Blood, vol. 121, no. 15, pp. 2845-2853. https://doi.org/10.1182/blood-2012-11-292037
Lunardi A, Guarnerio J, Wang G, Maeda T, Pandolfi PP. Role of LRF/Pokemon in lineage fate decisions. Blood. 2013 Apr 11;121(15):2845-2853. https://doi.org/10.1182/blood-2012-11-292037
Lunardi, Andrea ; Guarnerio, Jlenia ; Wang, Guocan ; Maeda, Takahiro ; Pandolfi, Pier Paolo. / Role of LRF/Pokemon in lineage fate decisions. In: Blood. 2013 ; Vol. 121, No. 15. pp. 2845-2853.
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