Role of microbiome in regulating the HPA axis and its relevance to allergy

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)

Abstract

There has been an increasing and intense interest in the role that gut bacteria play in maintaining the health of the host. Gut microbiota have an estimated mass of 1-2 kg, number 100 trillion and together possess 100 times the number of genes in the human genome. In addition to their well-established role in the postnatal maturation of the mammalian immune system, they are also responsible for an enormous array of metabolic activities that include effects on the digestion of food and the production of a host of biologically active substances. Moreover, it is also rapidly becoming apparent that the gut microbiome plays a major role in the development and regulation of neuroendocrine systems such as the hypothalamic-pituitary-adrenal axis, a central integrative system crucial for the successful physiological adaptation of the organism to stress. In fact, our previous study on gnotobiotic mice demonstrated that exposure to gut microbes is a postnatal environmental determinant that regulates the development of the hypothalamic-pituitary-adrenal axis stress response and also the set point for this axis.

Original languageEnglish
Title of host publicationAllergy and the Nervous System
EditorsJohn Bienenstock
Pages163-175
Number of pages13
DOIs
Publication statusPublished - Dec 1 2012

Publication series

NameChemical Immunology and Allergy
Volume98
ISSN (Print)1660-2242
ISSN (Electronic)1662-2898

Fingerprint

Microbiota
Hypersensitivity
Germ-Free Life
Physiological Adaptation
Neurosecretory Systems
Human Genome
Digestion
Immune System
Bacteria
Food
Health
Genes
Gastrointestinal Microbiome

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Sudo, N. (2012). Role of microbiome in regulating the HPA axis and its relevance to allergy. In J. Bienenstock (Ed.), Allergy and the Nervous System (pp. 163-175). (Chemical Immunology and Allergy; Vol. 98). https://doi.org/10.1159/00033651013

Role of microbiome in regulating the HPA axis and its relevance to allergy. / Sudo, Nobuyuki.

Allergy and the Nervous System. ed. / John Bienenstock. 2012. p. 163-175 (Chemical Immunology and Allergy; Vol. 98).

Research output: Chapter in Book/Report/Conference proceedingChapter

Sudo, N 2012, Role of microbiome in regulating the HPA axis and its relevance to allergy. in J Bienenstock (ed.), Allergy and the Nervous System. Chemical Immunology and Allergy, vol. 98, pp. 163-175. https://doi.org/10.1159/00033651013
Sudo N. Role of microbiome in regulating the HPA axis and its relevance to allergy. In Bienenstock J, editor, Allergy and the Nervous System. 2012. p. 163-175. (Chemical Immunology and Allergy). https://doi.org/10.1159/00033651013
Sudo, Nobuyuki. / Role of microbiome in regulating the HPA axis and its relevance to allergy. Allergy and the Nervous System. editor / John Bienenstock. 2012. pp. 163-175 (Chemical Immunology and Allergy).
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