Role of microbiome in regulating the HPA axis and its relevance to allergy

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

There has been an increasing and intense interest in the role that gut bacteria play in maintaining the health of the host. Gut microbiota have an estimated mass of 1- 2 kg, number 100 trillion and together possess 100 times the number of genes in the human genome. In addition to their wellestablished role in the postnatal maturation of the mammalian immune system, they are also responsible for an enormous array of metabolic activities that include effects on the digestion of food and the production of a host of biologically active substances. Moreover, it is also rapidly becoming apparent that the gut microbiome plays a major role in the development and regulation of neuroendocrine systems such as the hypothalamic- pituitary- adrenal axis, a central integrative system crucial for the successful physiological adaptation of the organism to stress. In fact, our previous study on gnotobiotic mice demonstrated that exposure to gut microbes is a postnatal environmental determinant that regulates the development of the hypothalamic- pituitary- adrenal axis stress response and also the set point for this axis.

Original languageEnglish
Title of host publicationChemical Immunology and Allergy
PublisherS. Karger AG
Pages163-175
Number of pages13
Volume98
ISBN (Electronic)9783805599856
ISBN (Print)9783805599849
DOIs
Publication statusPublished - Jun 22 2012

Fingerprint

Microbiota
Hypersensitivity
Germ-Free Life
Physiological Adaptation
Neurosecretory Systems
Human Genome
Digestion
Immune System
Bacteria
Food
Health
Genes
Gastrointestinal Microbiome

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Psychology(all)

Cite this

Sudo, N. (2012). Role of microbiome in regulating the HPA axis and its relevance to allergy. In Chemical Immunology and Allergy (Vol. 98, pp. 163-175). S. Karger AG. https://doi.org/10.1159/000336510

Role of microbiome in regulating the HPA axis and its relevance to allergy. / Sudo, Nobuyuki.

Chemical Immunology and Allergy. Vol. 98 S. Karger AG, 2012. p. 163-175.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sudo, N 2012, Role of microbiome in regulating the HPA axis and its relevance to allergy. in Chemical Immunology and Allergy. vol. 98, S. Karger AG, pp. 163-175. https://doi.org/10.1159/000336510
Sudo N. Role of microbiome in regulating the HPA axis and its relevance to allergy. In Chemical Immunology and Allergy. Vol. 98. S. Karger AG. 2012. p. 163-175 https://doi.org/10.1159/000336510
Sudo, Nobuyuki. / Role of microbiome in regulating the HPA axis and its relevance to allergy. Chemical Immunology and Allergy. Vol. 98 S. Karger AG, 2012. pp. 163-175
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