Role of microRNAs in solid tumors

Rie Hamano, Hideshi Ishii, Hiroshi Miyata, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Accumulating experimental evidence indi-cates that microRNAs play important roles in various biological processes, such as cell differ-entiation, proliferation, metabolism and apopto-sis. In addition, several reports concluded that altered expression of specific microRNA genes contributes to the initiation and progression of cancer. Here, we summarize the current knowl-edge about aberrant expression of various microRNAs in human solid cancers (e.g., lung, breast, and gastric cancers), their target pro-teins, and the relationship between their expression and response to chemotherapies. We also review the potential for using microRNAs as biomarkers for the diagnosis and cancer therapy. The development of treatment strategies against human solid cancers based on the profile and/or certain features of microRNAs is promising.

Original languageEnglish
Pages (from-to)5-16
Number of pages12
JournalJournal of Nucleic Acids Investigation
Volume2
Issue number1
DOIs
Publication statusPublished - 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry

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