Role of mitochondrial p32 in dendritic cell maturation

Kazuhito Gotoh, Dongchon Kang

Research output: Contribution to journalArticle

Abstract

Dendritic cells (DCs) are the most potent antigen-presenting cells and have a unique ability to induce primary immune responses. DC maturation induced by Toll-like receptor (TLR) agonists requires activation of downstream signal transduction and metabolic changes. DCs activated via TLRs have central roles mitochondrial matrix. p32/Clqbp is required for appropriate interleukin (IL)-6 production upon lipopolysaccharide (LPS) stimulation. However, the exact mechanisms of p32 functions in DCs remain unclear. In this review, we discuss p32-dependent metabolic pathway during DC activation.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalJapanese Journal of Clinical Chemistry
Volume49
Issue number2
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

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