Abstract
Dendritic cells (DCs) are the most potent antigen-presenting cells and have a unique ability to induce primary immune responses. DC maturation induced by Toll-like receptor (TLR) agonists requires activation of downstream signal transduction and metabolic changes. DCs activated via TLRs have central roles mitochondrial matrix. p32/Clqbp is required for appropriate interleukin (IL)-6 production upon lipopolysaccharide (LPS) stimulation. However, the exact mechanisms of p32 functions in DCs remain unclear. In this review, we discuss p32-dependent metabolic pathway during DC activation.
| Original language | English |
|---|---|
| Pages (from-to) | 117-123 |
| Number of pages | 7 |
| Journal | Japanese Journal of Clinical Chemistry |
| Volume | 49 |
| Issue number | 2 |
| Publication status | Published - 2020 |
All Science Journal Classification (ASJC) codes
- Clinical Biochemistry