TY - JOUR
T1 - Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice
AU - Teranishi, Hitoshi
AU - Hayashi, Masafumi
AU - Higa, Ryoko
AU - Mori, Kenji
AU - Miyazawa, Takashi
AU - Hino, Jun
AU - Amano, Yuichiro
AU - Tozawa, Ryuichi
AU - Ida, Takanori
AU - Hanada, Toshikatsu
AU - Miyazato, Mikiya
AU - Hanada, Reiko
AU - Kangawa, Kenji
AU - Nakao, Kazuwa
N1 - Funding Information:
We thank Nina Stanojevic for her technical assistance. We also thank Dr. Hiroshi Iwakura (Kyoto University) for kindly providing us with the vector pCAGEN and the transposase-encoding plasmid pCMV-SB100. This study was supported in part by Takeda Pharmaceutical Company. In addition, the study was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science ( 15K09427 ) and by grants from the Takeda Science Foundation, the Japan Foundation for Smoking Research, and The Naito Foundation (to R.H. ).
Funding Information:
We thank Nina Stanojevic for her technical assistance. We also thank Dr. Hiroshi Iwakura (Kyoto University) for kindly providing us with the vector pCAGEN and the transposase-encoding plasmid pCMV-SB100. This study was supported in part by Takeda Pharmaceutical Company. In addition, the study was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (15K09427) and by grants from the Takeda Science Foundation, the Japan Foundation for Smoking Research, and The Naito Foundation (to R.H.).
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/1
Y1 - 2018/1
N2 - Neuromedin U (NMU), a neuropeptide originally isolated from porcine spinal cord, has multiple physiological functions and is involved in obesity and inflammation. Excessive fat accumulation in the liver leads to non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), which is closely associated with obesity. NAFLD and NASH develop and progress via complex pathophysiological processes, and it remains unclear to what extend the NMU system contributes to the risk of obesity-related disorders such as NAFLD and NASH. Here, we demonstrate that the NMU system plays a role in NAFLD/NASH pathogenesis. In the normal mouse liver, NMU mRNA was not detectable, and expression of the mRNA encoding neuromedin U receptor 1 (NMUR1), the peripheral receptor of NMU, was low. However, the expression of both was significantly increased in the livers of NASH mice. Furthermore, overproduction of NMU induced the mouse liver by hydrodynamic injection, exacerbated NASH pathogenesis. These data indicate a novel role for the peripheral NMU system, providing new insights into the pathogenesis of NAFLD/NASH.
AB - Neuromedin U (NMU), a neuropeptide originally isolated from porcine spinal cord, has multiple physiological functions and is involved in obesity and inflammation. Excessive fat accumulation in the liver leads to non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), which is closely associated with obesity. NAFLD and NASH develop and progress via complex pathophysiological processes, and it remains unclear to what extend the NMU system contributes to the risk of obesity-related disorders such as NAFLD and NASH. Here, we demonstrate that the NMU system plays a role in NAFLD/NASH pathogenesis. In the normal mouse liver, NMU mRNA was not detectable, and expression of the mRNA encoding neuromedin U receptor 1 (NMUR1), the peripheral receptor of NMU, was low. However, the expression of both was significantly increased in the livers of NASH mice. Furthermore, overproduction of NMU induced the mouse liver by hydrodynamic injection, exacerbated NASH pathogenesis. These data indicate a novel role for the peripheral NMU system, providing new insights into the pathogenesis of NAFLD/NASH.
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U2 - 10.1016/j.peptides.2017.09.011
DO - 10.1016/j.peptides.2017.09.011
M3 - Article
C2 - 29017855
AN - SCOPUS:85032211741
SN - 0196-9781
VL - 99
SP - 134
EP - 141
JO - Peptides
JF - Peptides
ER -
