Role of potassium channels in cerebral blood vessels

Takanari Kitazono, Frank M. Faraci, Hisao Taguchi, Donald D. Heistad

Research output: Contribution to journalReview article

151 Citations (Scopus)

Abstract

Hyperpolarization of vascular muscle in response to activation of potassium channels is a major mechanism of vasodilatation. In cerebral blood vessels, four different potassium channels have been described: ATP-sensitive potassium channels, calcium-activated potassium channels, delayed rectifier potassium channels, and inward rectifier potassium channels. Summary of ReviewActivation of ATP-sensitive and calcium-activated potassium channels appears to play a major role in relaxation of cerebral arteries and arterioles in response to diverse stimuli, including receptor-mediated agonists, intracellular second messengers, and hypoxia. Both calcium-activated and delayed rectifier potassium channels may contribute to a negative feedback system that regulates tone in large cerebral arteries. The influence of ATP-sensitive and calcium-activated potassium channels is altered in disease states such as hypertension, diabetes, and atherosclerosis. ConclusionsActivation of potassium channels is a major mechanism of cerebral vasodilatation. Alteration of activity of potassium channels and impairment of vasodilatation may contribute to the development or maintenance of cerebral ischemia or vasospasm.

Original languageEnglish
Pages (from-to)1713-1723
Number of pages11
JournalStroke
Volume26
Issue number9
DOIs
Publication statusPublished - Jan 1 1995
Externally publishedYes

Fingerprint

Potassium Channels
Calcium-Activated Potassium Channels
Blood Vessels
Delayed Rectifier Potassium Channels
Vasodilation
Cerebral Arteries
Adenosine Triphosphate
Inwardly Rectifying Potassium Channel
Intracranial Vasospasm
KATP Channels
Arterioles
Second Messenger Systems
Brain Ischemia
Atherosclerosis
Maintenance
Hypertension
Calcium
Muscles

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

Cite this

Kitazono, T., Faraci, F. M., Taguchi, H., & Heistad, D. D. (1995). Role of potassium channels in cerebral blood vessels. Stroke, 26(9), 1713-1723. https://doi.org/10.1161/01.STR.26.9.1713

Role of potassium channels in cerebral blood vessels. / Kitazono, Takanari; Faraci, Frank M.; Taguchi, Hisao; Heistad, Donald D.

In: Stroke, Vol. 26, No. 9, 01.01.1995, p. 1713-1723.

Research output: Contribution to journalReview article

Kitazono, T, Faraci, FM, Taguchi, H & Heistad, DD 1995, 'Role of potassium channels in cerebral blood vessels', Stroke, vol. 26, no. 9, pp. 1713-1723. https://doi.org/10.1161/01.STR.26.9.1713
Kitazono, Takanari ; Faraci, Frank M. ; Taguchi, Hisao ; Heistad, Donald D. / Role of potassium channels in cerebral blood vessels. In: Stroke. 1995 ; Vol. 26, No. 9. pp. 1713-1723.
@article{9ad21275829441eda8851dd59dc6d710,
title = "Role of potassium channels in cerebral blood vessels",
abstract = "Hyperpolarization of vascular muscle in response to activation of potassium channels is a major mechanism of vasodilatation. In cerebral blood vessels, four different potassium channels have been described: ATP-sensitive potassium channels, calcium-activated potassium channels, delayed rectifier potassium channels, and inward rectifier potassium channels. Summary of ReviewActivation of ATP-sensitive and calcium-activated potassium channels appears to play a major role in relaxation of cerebral arteries and arterioles in response to diverse stimuli, including receptor-mediated agonists, intracellular second messengers, and hypoxia. Both calcium-activated and delayed rectifier potassium channels may contribute to a negative feedback system that regulates tone in large cerebral arteries. The influence of ATP-sensitive and calcium-activated potassium channels is altered in disease states such as hypertension, diabetes, and atherosclerosis. ConclusionsActivation of potassium channels is a major mechanism of cerebral vasodilatation. Alteration of activity of potassium channels and impairment of vasodilatation may contribute to the development or maintenance of cerebral ischemia or vasospasm.",
author = "Takanari Kitazono and Faraci, {Frank M.} and Hisao Taguchi and Heistad, {Donald D.}",
year = "1995",
month = "1",
day = "1",
doi = "10.1161/01.STR.26.9.1713",
language = "English",
volume = "26",
pages = "1713--1723",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Role of potassium channels in cerebral blood vessels

AU - Kitazono, Takanari

AU - Faraci, Frank M.

AU - Taguchi, Hisao

AU - Heistad, Donald D.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Hyperpolarization of vascular muscle in response to activation of potassium channels is a major mechanism of vasodilatation. In cerebral blood vessels, four different potassium channels have been described: ATP-sensitive potassium channels, calcium-activated potassium channels, delayed rectifier potassium channels, and inward rectifier potassium channels. Summary of ReviewActivation of ATP-sensitive and calcium-activated potassium channels appears to play a major role in relaxation of cerebral arteries and arterioles in response to diverse stimuli, including receptor-mediated agonists, intracellular second messengers, and hypoxia. Both calcium-activated and delayed rectifier potassium channels may contribute to a negative feedback system that regulates tone in large cerebral arteries. The influence of ATP-sensitive and calcium-activated potassium channels is altered in disease states such as hypertension, diabetes, and atherosclerosis. ConclusionsActivation of potassium channels is a major mechanism of cerebral vasodilatation. Alteration of activity of potassium channels and impairment of vasodilatation may contribute to the development or maintenance of cerebral ischemia or vasospasm.

AB - Hyperpolarization of vascular muscle in response to activation of potassium channels is a major mechanism of vasodilatation. In cerebral blood vessels, four different potassium channels have been described: ATP-sensitive potassium channels, calcium-activated potassium channels, delayed rectifier potassium channels, and inward rectifier potassium channels. Summary of ReviewActivation of ATP-sensitive and calcium-activated potassium channels appears to play a major role in relaxation of cerebral arteries and arterioles in response to diverse stimuli, including receptor-mediated agonists, intracellular second messengers, and hypoxia. Both calcium-activated and delayed rectifier potassium channels may contribute to a negative feedback system that regulates tone in large cerebral arteries. The influence of ATP-sensitive and calcium-activated potassium channels is altered in disease states such as hypertension, diabetes, and atherosclerosis. ConclusionsActivation of potassium channels is a major mechanism of cerebral vasodilatation. Alteration of activity of potassium channels and impairment of vasodilatation may contribute to the development or maintenance of cerebral ischemia or vasospasm.

UR - http://www.scopus.com/inward/record.url?scp=0029090483&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029090483&partnerID=8YFLogxK

U2 - 10.1161/01.STR.26.9.1713

DO - 10.1161/01.STR.26.9.1713

M3 - Review article

C2 - 7660420

AN - SCOPUS:0029090483

VL - 26

SP - 1713

EP - 1723

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 9

ER -