Role of premature leptin surge in obesity resulting from intrauterine undernutrition

Shigeo Yura, Hiroaki Itoh, Norimasa Sagawa, Hiroshi Yamamoto, Hiroaki Masuzaki, Kazuwa Nakao, Makoto Kawamura, Maki Takemura, Kazuyo Kakui, Yoshihiro Ogawa, Shingo Fujii

Research output: Contribution to journalArticle

314 Citations (Scopus)

Abstract

Intrauterine undernutrition is closely associated with obesity related to detrimental metabolic sequelae in adulthood. We report a mouse model in which offspring with fetal undernutrition (UN offspring), when fed a high-fat diet (HFD), develop pronounced weight gain and adiposity. In the neonatal period, UN offspring exhibited a premature onset of neonatal leptin surge compared to offspring with intrauterine normal nutrition (NN offspring). Unexpectedly, premature leptin surge generated in NN offspring by exogenous leptin administration led to accelerated weight gain with an HFD. Both UN offspring and neonatally leptin-treated NN offspring exhibited an impaired response to acute peripheral leptin administration on a regular chow diet (RCD) with impaired leptin transport to the brain as well as an increased density of hypothalamic nerve terminals. The present study suggests that the premature leptin surge alters energy regulation by the hypothalamus and contributes to "developmental origins of health and disease.".

Original languageEnglish
Pages (from-to)371-378
Number of pages8
JournalCell metabolism
Volume1
Issue number6
DOIs
Publication statusPublished - Jun 1 2005
Externally publishedYes

Fingerprint

Leptin
Malnutrition
Obesity
United Nations
High Fat Diet
Weight Gain
Adiposity
Hypothalamus
Diet
Health
Brain

All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

Yura, S., Itoh, H., Sagawa, N., Yamamoto, H., Masuzaki, H., Nakao, K., ... Fujii, S. (2005). Role of premature leptin surge in obesity resulting from intrauterine undernutrition. Cell metabolism, 1(6), 371-378. https://doi.org/10.1016/j.cmet.2005.05.005

Role of premature leptin surge in obesity resulting from intrauterine undernutrition. / Yura, Shigeo; Itoh, Hiroaki; Sagawa, Norimasa; Yamamoto, Hiroshi; Masuzaki, Hiroaki; Nakao, Kazuwa; Kawamura, Makoto; Takemura, Maki; Kakui, Kazuyo; Ogawa, Yoshihiro; Fujii, Shingo.

In: Cell metabolism, Vol. 1, No. 6, 01.06.2005, p. 371-378.

Research output: Contribution to journalArticle

Yura, S, Itoh, H, Sagawa, N, Yamamoto, H, Masuzaki, H, Nakao, K, Kawamura, M, Takemura, M, Kakui, K, Ogawa, Y & Fujii, S 2005, 'Role of premature leptin surge in obesity resulting from intrauterine undernutrition', Cell metabolism, vol. 1, no. 6, pp. 371-378. https://doi.org/10.1016/j.cmet.2005.05.005
Yura S, Itoh H, Sagawa N, Yamamoto H, Masuzaki H, Nakao K et al. Role of premature leptin surge in obesity resulting from intrauterine undernutrition. Cell metabolism. 2005 Jun 1;1(6):371-378. https://doi.org/10.1016/j.cmet.2005.05.005
Yura, Shigeo ; Itoh, Hiroaki ; Sagawa, Norimasa ; Yamamoto, Hiroshi ; Masuzaki, Hiroaki ; Nakao, Kazuwa ; Kawamura, Makoto ; Takemura, Maki ; Kakui, Kazuyo ; Ogawa, Yoshihiro ; Fujii, Shingo. / Role of premature leptin surge in obesity resulting from intrauterine undernutrition. In: Cell metabolism. 2005 ; Vol. 1, No. 6. pp. 371-378.
@article{88e95ed5c34946dd8ac14e296577a4d0,
title = "Role of premature leptin surge in obesity resulting from intrauterine undernutrition",
abstract = "Intrauterine undernutrition is closely associated with obesity related to detrimental metabolic sequelae in adulthood. We report a mouse model in which offspring with fetal undernutrition (UN offspring), when fed a high-fat diet (HFD), develop pronounced weight gain and adiposity. In the neonatal period, UN offspring exhibited a premature onset of neonatal leptin surge compared to offspring with intrauterine normal nutrition (NN offspring). Unexpectedly, premature leptin surge generated in NN offspring by exogenous leptin administration led to accelerated weight gain with an HFD. Both UN offspring and neonatally leptin-treated NN offspring exhibited an impaired response to acute peripheral leptin administration on a regular chow diet (RCD) with impaired leptin transport to the brain as well as an increased density of hypothalamic nerve terminals. The present study suggests that the premature leptin surge alters energy regulation by the hypothalamus and contributes to {"}developmental origins of health and disease.{"}.",
author = "Shigeo Yura and Hiroaki Itoh and Norimasa Sagawa and Hiroshi Yamamoto and Hiroaki Masuzaki and Kazuwa Nakao and Makoto Kawamura and Maki Takemura and Kazuyo Kakui and Yoshihiro Ogawa and Shingo Fujii",
year = "2005",
month = "6",
day = "1",
doi = "10.1016/j.cmet.2005.05.005",
language = "English",
volume = "1",
pages = "371--378",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - Role of premature leptin surge in obesity resulting from intrauterine undernutrition

AU - Yura, Shigeo

AU - Itoh, Hiroaki

AU - Sagawa, Norimasa

AU - Yamamoto, Hiroshi

AU - Masuzaki, Hiroaki

AU - Nakao, Kazuwa

AU - Kawamura, Makoto

AU - Takemura, Maki

AU - Kakui, Kazuyo

AU - Ogawa, Yoshihiro

AU - Fujii, Shingo

PY - 2005/6/1

Y1 - 2005/6/1

N2 - Intrauterine undernutrition is closely associated with obesity related to detrimental metabolic sequelae in adulthood. We report a mouse model in which offspring with fetal undernutrition (UN offspring), when fed a high-fat diet (HFD), develop pronounced weight gain and adiposity. In the neonatal period, UN offspring exhibited a premature onset of neonatal leptin surge compared to offspring with intrauterine normal nutrition (NN offspring). Unexpectedly, premature leptin surge generated in NN offspring by exogenous leptin administration led to accelerated weight gain with an HFD. Both UN offspring and neonatally leptin-treated NN offspring exhibited an impaired response to acute peripheral leptin administration on a regular chow diet (RCD) with impaired leptin transport to the brain as well as an increased density of hypothalamic nerve terminals. The present study suggests that the premature leptin surge alters energy regulation by the hypothalamus and contributes to "developmental origins of health and disease.".

AB - Intrauterine undernutrition is closely associated with obesity related to detrimental metabolic sequelae in adulthood. We report a mouse model in which offspring with fetal undernutrition (UN offspring), when fed a high-fat diet (HFD), develop pronounced weight gain and adiposity. In the neonatal period, UN offspring exhibited a premature onset of neonatal leptin surge compared to offspring with intrauterine normal nutrition (NN offspring). Unexpectedly, premature leptin surge generated in NN offspring by exogenous leptin administration led to accelerated weight gain with an HFD. Both UN offspring and neonatally leptin-treated NN offspring exhibited an impaired response to acute peripheral leptin administration on a regular chow diet (RCD) with impaired leptin transport to the brain as well as an increased density of hypothalamic nerve terminals. The present study suggests that the premature leptin surge alters energy regulation by the hypothalamus and contributes to "developmental origins of health and disease.".

UR - http://www.scopus.com/inward/record.url?scp=24144486246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24144486246&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2005.05.005

DO - 10.1016/j.cmet.2005.05.005

M3 - Article

C2 - 16054086

AN - SCOPUS:24144486246

VL - 1

SP - 371

EP - 378

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 6

ER -