TY - JOUR
T1 - Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions
AU - Shiratori-Hayashi, Miho
AU - Tsuda, Makoto
N1 - Funding Information:
This work was supported by JSPS KAKENHI Grant Numbers JP19K22500 , JP19H05658 (M.T.), JP16H06237 , JP19K16260 (M.S-H.), by the Practical Research Project for Allergic Diseases and Immunology (Research on Allergic Diseases and Immunology) from AMED under Grant Number JP18ek0410034 (M.T., M.S-H.), by Astellas Foundation for Research on Metabolic Disorders, by the Yamaguchi Foundation (M.S-H), by the Core Research for Evolutional Science and Technology program from AMED under Grant Number JP19gm0910006 (M.T.), by Naito Foundation (M.T.) and by Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED under Grant Number JP19am0101091 (M.T.). We thank Lisa Kreiner, PhD, from Edanz Group ( https://en-author-services.edanzgroup.com/ ) for editing a draft of this manuscript.
Funding Information:
This work was supported by JSPS KAKENHI Grant Numbers JP19K22500, JP19H05658 (M.T.), JP16H06237, JP19K16260 (M.S-H.), by the Practical Research Project for Allergic Diseases and Immunology (Research on Allergic Diseases and Immunology) from AMED under Grant Number JP18ek0410034 (M.T. M.S-H.), by Astellas Foundation for Research on Metabolic Disorders, by the Yamaguchi Foundation (M.S-H), by the Core Research for Evolutional Science and Technology program from AMED under Grant Number JP19gm0910006 (M.T.), by Naito Foundation (M.T.) and by Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED under Grant Number JP19am0101091 (M.T.). We thank Lisa Kreiner, PhD, from Edanz Group (https://en-author-services.edanzgroup.com/) for editing a draft of this manuscript.
Publisher Copyright:
© 2020 The Authors
PY - 2020/11
Y1 - 2020/11
N2 - Astrocytes are the most abundant glial cells in the central nervous system (CNS), including the spinal cord. Neuronal damage induces astrocytes to become reactive and contribute to various CNS pathologies. Recent studies have demonstrated that astrocytes in the spinal dorsal horn (SDH) become reactive in a transcription factor signal transducer and activator of transcription 3-dependent manner without neuronal damage under chronic itch conditions, causing release of the factor lipocalin-2, leading to induction of sensitization of gastrin releasing peptide-induced chemical itch signaling in the SDH. In this review, we describe recent advances in our understanding of SDH neuronal pathways for itch transmission, the mechanisms of SDH astrocytic activation and its contribution to abnormal itch processing and discuss the role of reactive astrocytes in the SDH in abnormal sensory processing under chronic itch conditions.
AB - Astrocytes are the most abundant glial cells in the central nervous system (CNS), including the spinal cord. Neuronal damage induces astrocytes to become reactive and contribute to various CNS pathologies. Recent studies have demonstrated that astrocytes in the spinal dorsal horn (SDH) become reactive in a transcription factor signal transducer and activator of transcription 3-dependent manner without neuronal damage under chronic itch conditions, causing release of the factor lipocalin-2, leading to induction of sensitization of gastrin releasing peptide-induced chemical itch signaling in the SDH. In this review, we describe recent advances in our understanding of SDH neuronal pathways for itch transmission, the mechanisms of SDH astrocytic activation and its contribution to abnormal itch processing and discuss the role of reactive astrocytes in the SDH in abnormal sensory processing under chronic itch conditions.
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U2 - 10.1016/j.jphs.2020.07.010
DO - 10.1016/j.jphs.2020.07.010
M3 - Review article
C2 - 32800684
AN - SCOPUS:85089396208
VL - 144
SP - 147
EP - 150
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8613
IS - 3
ER -