Role of STIM-dependent Ca2+ influx in regulatory B cells

Masanori Matsumoto, Yoshihiro Baba

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

B cells positively regulate immune responses through antibody production and ešector T cell dišerentiation. In addition to such protective roles against pathogenesis, B cells also serve as negative regulators of autoimmunity by secreting an anti-inflammatory cytokine, interleukin-10 (IL-10). These B cell functions are caused by encountering their cognate antigens through their B cell receptors (BCR). A central response of BCR stimulation is intracellular Ca2+ elevation, which is derived mainly from two pathways, Ca2+ release from endoplasmic reticulum (ER) stores and Ca2+ influx from the extracellular space across the plasma membrane. Although a chief Ca2+ entry pathway in immune cells is store-operated Ca2+ (SOC) influx, which is triggered by depletion of Ca2+ from ER, its physiological role in B cells remains elusive. Stromal interaction molecules (STIM), which consist of STIM1 and its homolog, STIM2, serve as ER calcium sensors and are essential for SOC influx after antigen stimulation. We have recently found that STIM1- and STIM2-in-duced SOC influx is critical for regulatory B cell function required to limit experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Even through several B cell populations have been reported to suppress inflammation of autoimmune diseases through production of IL-10, which subset of them exerts their regulatory function during EAE is not fully understood. This review focuses on our recent progress in the role of STIM-dependent SOC influx as a key signal for B cell regulatory function and the latest & findings for understanding how regulatory B cells suppress the development of EAE.

Original languageEnglish
Pages (from-to)419-425
Number of pages7
JournalYakugaku Zasshi
Volume133
Issue number4
DOIs
Publication statusPublished - Apr 1 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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