TY - JOUR
T1 - Role of tumor angiogenesis in gallbladder carcinoma
T2 - With special reference to thymidine phosphorylase
AU - Harino, Yukari
AU - Imura, Satoru
AU - Kanemura, Hirofumi
AU - Morine, Yuji
AU - Fujii, Masahiko
AU - Ikegami, Toru
AU - Uehara, Hisanori
AU - Shimada, Mitsuo
PY - 2008/10
Y1 - 2008/10
N2 - Background. Angiogenesis plays an important role in tumor growth and metastasis. Thymidine phosphorylase (TP), as well as vascular endothelial growth factor (VEGF), is known to be an angiogenic factor. The aim of this study was to clarify whether TP regulates angiogenesis and to determine the clinicopathological role of TP expression in gallbladder cancer. Methods. Thirty-seven patients with gallbladder cancer who underwent curative surgical resection were included in this study, and we evaluated results in 21 of these patients in whom TP gene expression could be measured. Intratumoral TP gene expression was evaluated using the Danenberg tumor profile method. TP gene expression was classified into two groups according to median values: high and low. Tissue TP expression was classified into two groups (positive and negative) by a pathologist. Clinicopathological variables were compared between groups with high and low TP gene expression (TP high and TP low groups). Results. No correlation was observed between TP gene expression (high and low groups) and any clinicopathological variables except survival rate. However, the survival rate was significantly lower in the TP high group (P < 0.05). TP gene expression was associated with tissue TP expression evaluated by immunohistochemical staining (P < 0.05). In addition, tumor microvessel density was significantly higher in the TP high group (P < 0.05). Conclusion. Expression of the TP gene in gallbladder carcinoma is associated with angiogenesis and may be a new independent prognostic parameter.
AB - Background. Angiogenesis plays an important role in tumor growth and metastasis. Thymidine phosphorylase (TP), as well as vascular endothelial growth factor (VEGF), is known to be an angiogenic factor. The aim of this study was to clarify whether TP regulates angiogenesis and to determine the clinicopathological role of TP expression in gallbladder cancer. Methods. Thirty-seven patients with gallbladder cancer who underwent curative surgical resection were included in this study, and we evaluated results in 21 of these patients in whom TP gene expression could be measured. Intratumoral TP gene expression was evaluated using the Danenberg tumor profile method. TP gene expression was classified into two groups according to median values: high and low. Tissue TP expression was classified into two groups (positive and negative) by a pathologist. Clinicopathological variables were compared between groups with high and low TP gene expression (TP high and TP low groups). Results. No correlation was observed between TP gene expression (high and low groups) and any clinicopathological variables except survival rate. However, the survival rate was significantly lower in the TP high group (P < 0.05). TP gene expression was associated with tissue TP expression evaluated by immunohistochemical staining (P < 0.05). In addition, tumor microvessel density was significantly higher in the TP high group (P < 0.05). Conclusion. Expression of the TP gene in gallbladder carcinoma is associated with angiogenesis and may be a new independent prognostic parameter.
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U2 - 10.1007/s10147-008-0778-y
DO - 10.1007/s10147-008-0778-y
M3 - Article
C2 - 18946757
AN - SCOPUS:54849422245
VL - 13
SP - 452
EP - 457
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
SN - 1341-9625
IS - 5
ER -
