TY - JOUR
T1 - Roles of Brain Lipids in Glial Activation
AU - Hossain, Md Shamim
AU - Katafuchi, Toshihiko
N1 - Funding Information:
This work was supported by JSPS KAKENHI Grant Number 26460320 to T. Katafuchi and JSPS Grant-in-Aid for Young Scientists (Wakate B) [16K19007] to MS Hossain.
PY - 2016
Y1 - 2016
N2 - Lipids were believed to be the major components of the brain structure. However, recent accumulated findings show that they can also play various roles in the brain, inducing cellular signaling, protecting neuronal cell death, preventing glial activation and even maintaining division of neural stem cells. In the present review, we first summarize physiological roles of brain lipids, then focus on ether-type glycerophospholipids, plasmalogens (Pls) showing recent evidences of how Pls can modulate the cellular signaling in the brain to maintain its integrity and to protect from the glial activation. Finally, we discuss the differential effects of other brain lipids in the glial activation.
AB - Lipids were believed to be the major components of the brain structure. However, recent accumulated findings show that they can also play various roles in the brain, inducing cellular signaling, protecting neuronal cell death, preventing glial activation and even maintaining division of neural stem cells. In the present review, we first summarize physiological roles of brain lipids, then focus on ether-type glycerophospholipids, plasmalogens (Pls) showing recent evidences of how Pls can modulate the cellular signaling in the brain to maintain its integrity and to protect from the glial activation. Finally, we discuss the differential effects of other brain lipids in the glial activation.
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U2 - 10.3233/NIB-160120
DO - 10.3233/NIB-160120
M3 - Review article
AN - SCOPUS:84998693451
SN - 1878-948X
VL - 6
SP - 61
EP - 67
JO - Advances in Neuroimmune Biology
JF - Advances in Neuroimmune Biology
IS - 2
ER -