Roles of glutamate receptors in long-term potentiation at hippocampal mossy fiber synapses

Isao Ito, Hiroyuki Sugiyama

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82 Citations (Scopus)

Abstract

We have investigated the roles of glutamate (Glu) receptors in the mechanism of long-term potentiation observed in rat hippocampal mossy fiber synapses (MF- LTP). The mossy fiber responses were almost completely suppressed by ionotropic Glu receptor (iGIuR) antago- nists both before and after the induction of LTP. However, tetanic stimulation produced robust LTP even when the synaptic transmission was blocked postsynaptically by iGIuR antagonists. In contrast, when the transmission was blocked presynaptically by Ca2+-free media, tetanic stimulation produced no LTP. D, L.-2-amino-3-phosphono- propionate (D, L-AP3), a metabotropic Glureceptor (mGluR) antagonist, inhibited the induction of MF-LTP. Perfusion with ibotenate, a mGluR agonist, induced long-lasting enhancement of the mossy fiber responses without tetanic stimulation, and this ibotenate-induced potentiation was antagonized by D, L-AP3.

Original languageEnglish
Pages (from-to)333-336
Number of pages4
JournalNeuroReport
Volume2
Issue number6
DOIs
Publication statusPublished - Jun 1991

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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