Roles of glutamate receptors in long-term potentiation at hippocampal mossy fiber synapses

Isao Ito, Hiroyuki Sugiyama

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

We have investigated the roles of glutamate (Glu) receptors in the mechanism of long-term potentiation observed in rat hippocampal mossy fiber synapses (MF- LTP). The mossy fiber responses were almost completely suppressed by ionotropic Glu receptor (iGIuR) antago- nists both before and after the induction of LTP. However, tetanic stimulation produced robust LTP even when the synaptic transmission was blocked postsynaptically by iGIuR antagonists. In contrast, when the transmission was blocked presynaptically by Ca2+-free media, tetanic stimulation produced no LTP. D, L.-2-amino-3-phosphono- propionate (D, L-AP3), a metabotropic Glureceptor (mGluR) antagonist, inhibited the induction of MF-LTP. Perfusion with ibotenate, a mGluR agonist, induced long-lasting enhancement of the mossy fiber responses without tetanic stimulation, and this ibotenate-induced potentiation was antagonized by D, L-AP3.

Original languageEnglish
Pages (from-to)333-336
Number of pages4
JournalNeuroReport
Volume2
Issue number6
DOIs
Publication statusPublished - Jan 1 1991

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Hippocampal Mossy Fibers
Long-Term Potentiation
Glutamate Receptors
Synapses
Ionotropic Glutamate Receptors
Excitatory Amino Acid Antagonists
Propionates
Synaptic Transmission
Perfusion
2-amino-3-phosphonopropionic acid

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Roles of glutamate receptors in long-term potentiation at hippocampal mossy fiber synapses. / Ito, Isao; Sugiyama, Hiroyuki.

In: NeuroReport, Vol. 2, No. 6, 01.01.1991, p. 333-336.

Research output: Contribution to journalArticle

Ito, Isao ; Sugiyama, Hiroyuki. / Roles of glutamate receptors in long-term potentiation at hippocampal mossy fiber synapses. In: NeuroReport. 1991 ; Vol. 2, No. 6. pp. 333-336.
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