TY - JOUR
T1 - Roles of glutamate receptors in long-term potentiation at hippocampal mossy fiber synapses
AU - Ito, Isao
AU - Sugiyama, Hiroyuki
PY - 1991/6
Y1 - 1991/6
N2 - We have investigated the roles of glutamate (Glu) receptors in the mechanism of long-term potentiation observed in rat hippocampal mossy fiber synapses (MF- LTP). The mossy fiber responses were almost completely suppressed by ionotropic Glu receptor (iGIuR) antago- nists both before and after the induction of LTP. However, tetanic stimulation produced robust LTP even when the synaptic transmission was blocked postsynaptically by iGIuR antagonists. In contrast, when the transmission was blocked presynaptically by Ca2+-free media, tetanic stimulation produced no LTP. D, L.-2-amino-3-phosphono- propionate (D, L-AP3), a metabotropic Glureceptor (mGluR) antagonist, inhibited the induction of MF-LTP. Perfusion with ibotenate, a mGluR agonist, induced long-lasting enhancement of the mossy fiber responses without tetanic stimulation, and this ibotenate-induced potentiation was antagonized by D, L-AP3.
AB - We have investigated the roles of glutamate (Glu) receptors in the mechanism of long-term potentiation observed in rat hippocampal mossy fiber synapses (MF- LTP). The mossy fiber responses were almost completely suppressed by ionotropic Glu receptor (iGIuR) antago- nists both before and after the induction of LTP. However, tetanic stimulation produced robust LTP even when the synaptic transmission was blocked postsynaptically by iGIuR antagonists. In contrast, when the transmission was blocked presynaptically by Ca2+-free media, tetanic stimulation produced no LTP. D, L.-2-amino-3-phosphono- propionate (D, L-AP3), a metabotropic Glureceptor (mGluR) antagonist, inhibited the induction of MF-LTP. Perfusion with ibotenate, a mGluR agonist, induced long-lasting enhancement of the mossy fiber responses without tetanic stimulation, and this ibotenate-induced potentiation was antagonized by D, L-AP3.
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U2 - 10.1097/00001756-199106000-00008
DO - 10.1097/00001756-199106000-00008
M3 - Article
C2 - 1680482
AN - SCOPUS:0025732103
SN - 0959-4965
VL - 2
SP - 333
EP - 336
JO - NeuroReport
JF - NeuroReport
IS - 6
ER -