Roles of heparan sulfate in mammalian brain development: Current views based on the findings from ext1 conditional knockout studies

Yu Yamaguchi, Masaru Inatani, Yoshihiro Matsumoto, Junko Ogawa, Fumitoshi Irie

Research output: Chapter in Book/Report/Conference proceedingChapter

31 Citations (Scopus)

Abstract

Development of the mammalian central nervous system proceeds roughly in four major steps, namely the patterning of the neural tube, generation of neurons from neural stem cells and their migration to genetically predetermined destinations, extension of axons and dendrites toward target neurons to form neural circuits, and formation of synaptic contacts. Earlier studies on spatiotemporal expression patterns and in vitro function of heparan sulfate (HS) suggested that HS is functionally involved in various aspects of neural development. Recent studies using knockout of genes involved in HS biosynthesis have provided more physiologically relevant information as to the role of HS in mammalian neural development. This chapter reviews the current understanding of the in vivo function of HS deduced from the phenotypes of conditional Ext1 knockout mice.

Original languageEnglish
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Pages133-152
Number of pages20
EditionC
DOIs
Publication statusPublished - Jan 1 2010

Publication series

NameProgress in Molecular Biology and Translational Science
NumberC
Volume93
ISSN (Print)1877-1173

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology

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    Yamaguchi, Y., Inatani, M., Matsumoto, Y., Ogawa, J., & Irie, F. (2010). Roles of heparan sulfate in mammalian brain development: Current views based on the findings from ext1 conditional knockout studies. In Progress in Molecular Biology and Translational Science (C ed., pp. 133-152). (Progress in Molecular Biology and Translational Science; Vol. 93, No. C). Elsevier B.V.. https://doi.org/10.1016/S1877-1173(10)93007-X