Abstract
In the mouse olfactory epithelium, there are about ten million olfactory sensory neurons, each expressing a single type of odorant receptor out of ∼1000. Olfactory sensory neurons expressing the same odorant receptor converge their axons to a specific set of glomeruli on the olfactory bulb. How odorant receptors play an instructive role in the projection of axons to the olfactory bulb has been one of the major issues of developmental neurobiology. Recent studies revealed previously overlooked roles of odorant receptor-derived cAMP signals in the axonal projection of olfactory sensory neurons; the levels of cAMP and neuronal activity appear to determine the expression levels of axon guidance/sorting molecules and thereby direct the axonal projection of olfactory sensory neurons. These findings provide new insights as to how peripheral inputs instruct neuronal circuit formation in the mammalian brain.
| Original language | English |
|---|---|
| Pages (from-to) | 507-515 |
| Number of pages | 9 |
| Journal | Current Opinion in Neurobiology |
| Volume | 17 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 1 2007 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
Cite this
Roles of odorant receptors in projecting axons in the mouse olfactory system. / Imai, Takeshi; Sakano, Hitoshi.
In: Current Opinion in Neurobiology, Vol. 17, No. 5, 01.10.2007, p. 507-515.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Roles of odorant receptors in projecting axons in the mouse olfactory system
AU - Imai, Takeshi
AU - Sakano, Hitoshi
PY - 2007/10/1
Y1 - 2007/10/1
N2 - In the mouse olfactory epithelium, there are about ten million olfactory sensory neurons, each expressing a single type of odorant receptor out of ∼1000. Olfactory sensory neurons expressing the same odorant receptor converge their axons to a specific set of glomeruli on the olfactory bulb. How odorant receptors play an instructive role in the projection of axons to the olfactory bulb has been one of the major issues of developmental neurobiology. Recent studies revealed previously overlooked roles of odorant receptor-derived cAMP signals in the axonal projection of olfactory sensory neurons; the levels of cAMP and neuronal activity appear to determine the expression levels of axon guidance/sorting molecules and thereby direct the axonal projection of olfactory sensory neurons. These findings provide new insights as to how peripheral inputs instruct neuronal circuit formation in the mammalian brain.
AB - In the mouse olfactory epithelium, there are about ten million olfactory sensory neurons, each expressing a single type of odorant receptor out of ∼1000. Olfactory sensory neurons expressing the same odorant receptor converge their axons to a specific set of glomeruli on the olfactory bulb. How odorant receptors play an instructive role in the projection of axons to the olfactory bulb has been one of the major issues of developmental neurobiology. Recent studies revealed previously overlooked roles of odorant receptor-derived cAMP signals in the axonal projection of olfactory sensory neurons; the levels of cAMP and neuronal activity appear to determine the expression levels of axon guidance/sorting molecules and thereby direct the axonal projection of olfactory sensory neurons. These findings provide new insights as to how peripheral inputs instruct neuronal circuit formation in the mammalian brain.
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UR - http://www.scopus.com/inward/citedby.url?scp=37549008306&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2007.08.002
DO - 10.1016/j.conb.2007.08.002
M3 - Review article
C2 - 17935969
AN - SCOPUS:37549008306
VL - 17
SP - 507
EP - 515
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
IS - 5
ER -