Roles of prostaglandins and leukotrienes in acute inflammation caused by bacterial infection

Y. Yoshikai

    Research output: Contribution to journalReview article

    45 Citations (Scopus)

    Abstract

    Prostanoids, including prostaglandins and thromboxanes, are generated by the phospholipase A2/cyclooxygenase pathway, and leukotrienes are generated by the 5-lipoxygenase pathway from arachidonic acid. At physiological concentrations, vasodilator prostaglandins enhance the vascular permeability effects of histamine and bradykinin, and leukotrienes are important mediators of leukocyte accumulation during acute inflammation. On the other hand, prostaglandin metabolites such as cyclopentenone prostaglandins contribute to the resolution of acute inflammation through inhibition of nuclear factor-κB activation. Thus, arachidonic acid oxygenation products mediate diverse effects that induce and resolve acute inflammation caused by bacterial infection.

    Original languageEnglish
    Pages (from-to)257-263
    Number of pages7
    JournalCurrent Opinion in Infectious Diseases
    Volume14
    Issue number3
    DOIs
    Publication statusPublished - Jan 1 2001

    All Science Journal Classification (ASJC) codes

    • Microbiology (medical)
    • Infectious Diseases

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