Roles of RORγt+ innate lymphoid cells in mucosal tissues of mouse and human

Research output: Contribution to journalArticle

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Abstract

Innate Lymphoid cells (ILCs) are recently defined lymphocytes composed of several subsets such as Natural Killer (NK), Natural Helper (NH) and RORγt+ cells, which have no antigen receptors but exhibit rapid cytokine production after stimulation. Murine RORγt+ ILCs can be classified either as CCR6+c-kithighIL-7Rahigh or CCR6-NKp46+ cells. The former ones play roles on the formation of secondary lymphoid tissues and the later ones contribute to the maintenance of intestinal epithelial integrity by producing IL-22. Human fetal intestine, tonsil and lympho nodes harbor both NKp44 positive and negative RORγt+ ILC subsets. Since human Crohn's disease patients have increased number of RORγt+ ILCs in the in‰amed intestine, roles of RORγt+ ILCs on the pathogenesis of Crohn's disease became of great interest.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalJapanese Journal of Clinical Immunology
Volume36
Issue number1
DOIs
Publication statusPublished - Jan 1 2013
Externally publishedYes

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Mucous Membrane
Lymphocytes
Crohn Disease
Intestines
Antigen Receptors
Palatine Tonsil
Lymphoid Tissue
Helper-Inducer T-Lymphocytes
Maintenance
Cytokines

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Roles of RORγt+ innate lymphoid cells in mucosal tissues of mouse and human. / Sawa, Shinichiro.

In: Japanese Journal of Clinical Immunology, Vol. 36, No. 1, 01.01.2013, p. 11-16.

Research output: Contribution to journalArticle

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