Roles of ubiquitin in autophagy and cell death

Carlos Gómez-Díaz, Fumiyo Ikeda

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

The balance between cell survival and cell death is often lost in human pathologies such as inflammation and cancer. Autophagy plays a critical role in cell survival: essential nutrients are generated by autophagy-dependent degradation and recycling of cellular garbage. On the other hand, cell death is induced by different programs, such as apoptosis, pyroptosis, and necroptosis. Emerging evidence is revealing how cell survival and cell death pathways are coordinated to determine cell fate. For instance, posttranslational modification of proteins with ubiquitin regulates many steps of autophagy and cell death pathways. In this review article, we will discuss how the ubiquitin system influences cell death and autophagy.

Original languageEnglish
Pages (from-to)125-135
Number of pages11
JournalSeminars in Cell and Developmental Biology
Volume93
DOIs
Publication statusPublished - Sep 2019

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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