Abstract
The balance between cell survival and cell death is often lost in human pathologies such as inflammation and cancer. Autophagy plays a critical role in cell survival: essential nutrients are generated by autophagy-dependent degradation and recycling of cellular garbage. On the other hand, cell death is induced by different programs, such as apoptosis, pyroptosis, and necroptosis. Emerging evidence is revealing how cell survival and cell death pathways are coordinated to determine cell fate. For instance, posttranslational modification of proteins with ubiquitin regulates many steps of autophagy and cell death pathways. In this review article, we will discuss how the ubiquitin system influences cell death and autophagy.
| Original language | English |
|---|---|
| Pages (from-to) | 125-135 |
| Number of pages | 11 |
| Journal | Seminars in Cell and Developmental Biology |
| Volume | 93 |
| DOIs | |
| Publication status | Published - Sep 2019 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Developmental Biology
- Cell Biology
Cite this
Roles of ubiquitin in autophagy and cell death. / Gómez-Díaz, Carlos; Ikeda, Fumiyo.
In: Seminars in Cell and Developmental Biology, Vol. 93, 09.2019, p. 125-135.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Roles of ubiquitin in autophagy and cell death
AU - Gómez-Díaz, Carlos
AU - Ikeda, Fumiyo
PY - 2019/9
Y1 - 2019/9
N2 - The balance between cell survival and cell death is often lost in human pathologies such as inflammation and cancer. Autophagy plays a critical role in cell survival: essential nutrients are generated by autophagy-dependent degradation and recycling of cellular garbage. On the other hand, cell death is induced by different programs, such as apoptosis, pyroptosis, and necroptosis. Emerging evidence is revealing how cell survival and cell death pathways are coordinated to determine cell fate. For instance, posttranslational modification of proteins with ubiquitin regulates many steps of autophagy and cell death pathways. In this review article, we will discuss how the ubiquitin system influences cell death and autophagy.
AB - The balance between cell survival and cell death is often lost in human pathologies such as inflammation and cancer. Autophagy plays a critical role in cell survival: essential nutrients are generated by autophagy-dependent degradation and recycling of cellular garbage. On the other hand, cell death is induced by different programs, such as apoptosis, pyroptosis, and necroptosis. Emerging evidence is revealing how cell survival and cell death pathways are coordinated to determine cell fate. For instance, posttranslational modification of proteins with ubiquitin regulates many steps of autophagy and cell death pathways. In this review article, we will discuss how the ubiquitin system influences cell death and autophagy.
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UR - http://www.scopus.com/inward/citedby.url?scp=85053004894&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2018.09.004
DO - 10.1016/j.semcdb.2018.09.004
M3 - Review article
C2 - 30195063
AN - SCOPUS:85053004894
VL - 93
SP - 125
EP - 135
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
SN - 1084-9521
ER -