TY - JOUR
T1 - Roles of ubiquitin in autophagy and cell death
AU - Gómez-Díaz, Carlos
AU - Ikeda, Fumiyo
N1 - Funding Information:
Research in Ikeda Lab is supported by the FWF standalone grant, Austrian science fund [P 25508 ]; the ERC consolidator grant [LUbi, 614711 ]; the COST, European Cooperation in Science and Technology [PROTEOSTASIS BM1307 ]; and the Austrian Academy of Sciences.
Publisher Copyright:
© 2018 The Authors
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/9
Y1 - 2019/9
N2 - The balance between cell survival and cell death is often lost in human pathologies such as inflammation and cancer. Autophagy plays a critical role in cell survival: essential nutrients are generated by autophagy-dependent degradation and recycling of cellular garbage. On the other hand, cell death is induced by different programs, such as apoptosis, pyroptosis, and necroptosis. Emerging evidence is revealing how cell survival and cell death pathways are coordinated to determine cell fate. For instance, posttranslational modification of proteins with ubiquitin regulates many steps of autophagy and cell death pathways. In this review article, we will discuss how the ubiquitin system influences cell death and autophagy.
AB - The balance between cell survival and cell death is often lost in human pathologies such as inflammation and cancer. Autophagy plays a critical role in cell survival: essential nutrients are generated by autophagy-dependent degradation and recycling of cellular garbage. On the other hand, cell death is induced by different programs, such as apoptosis, pyroptosis, and necroptosis. Emerging evidence is revealing how cell survival and cell death pathways are coordinated to determine cell fate. For instance, posttranslational modification of proteins with ubiquitin regulates many steps of autophagy and cell death pathways. In this review article, we will discuss how the ubiquitin system influences cell death and autophagy.
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U2 - 10.1016/j.semcdb.2018.09.004
DO - 10.1016/j.semcdb.2018.09.004
M3 - Review article
C2 - 30195063
AN - SCOPUS:85053004894
VL - 93
SP - 125
EP - 135
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
SN - 1084-9521
ER -