ROS-mediated synthetic growth defect caused by impaired metabolism of sphingolipids and phosphatidylserine in budding yeast

Takumi Toda, Atsuya Urita, Ayano Koga, Chihiro Takayama, Motohiro Tani

Research output: Contribution to journalArticlepeer-review

Abstract

Previously, we found that yeast exhibits a strong growth defect with the combination of a lack of gene involved in structural modification of sphingolipids and repression of the phosphatidylserine synthase gene. Here we found that the double gene mutation causes reactive oxygen species-mediated cell growth defect, which is suppressed by deletion of LEM3 encoding the subunit of phospholipid flippase.

Original languageEnglish
Pages (from-to)2529-2532
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume84
Issue number12
DOIs
Publication statusPublished - Dec 1 2020

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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