Ru(CO)-salen-catalyzed synthesis of enantiopure aziridinyl ketones and formal asymmetric synthesis of (+)-PD 128907

Yasuaki Fukunaga, Tatsuya Uchida, Yutaro Ito, Kenji Matsumoto, Tsutomu Katsuki

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Aziridination of vinyl ketones using SESN3 in the presence Ru(CO)-salen complex 1 provides the enantiopure aziridinyl ketones that can serve as useful chiral building blocks. A formal asymmetric synthesis of (+)-PD 128907 was achieved in an eight-step sequence via aziridination.

Original languageEnglish
Pages (from-to)4658-4661
Number of pages4
JournalOrganic Letters
Volume14
Issue number17
DOIs
Publication statusPublished - Sep 7 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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