TY - JOUR
T1 - Ru(PPh3)(OH)-salen complex
T2 - a designer catalyst for chemoselective aerobic oxidation of primary alcohols
AU - Mizoguchi, Hirotaka
AU - Uchida, Tatsuya
AU - Ishida, Kohichi
AU - Katsuki, Tsutomu
N1 - Funding Information:
Financial support (Specially Promoted Research 18002011 and the Global COE Program, ‘Science for Future Molecular Systems’) from a Grant-in-Aid for Scientific Research from MEXT, Japan, is gratefully acknowledged.
PY - 2009/7/1
Y1 - 2009/7/1
N2 - Based on the analysis of the mechanism of aerobic oxidation of alcohols using Ru(NO)-salen catalyst, we designed a new complex, Ru(PPh3)(OH)-salen 3, which was proved to be an excellent catalyst for chemoselective aerobic oxidation of primary alcohols to the aldehydes in the presence of secondary alcohols under ambient and non-irradiated conditions. Complex 3 was also successfully applied to the oxidation of 1-phenyl-1,n-diols to the lactols or the n-hydroxy aldehyde. It is of note that selective oxidation of primary alcohols was achieved even in the presence of activated secondary alcohols.
AB - Based on the analysis of the mechanism of aerobic oxidation of alcohols using Ru(NO)-salen catalyst, we designed a new complex, Ru(PPh3)(OH)-salen 3, which was proved to be an excellent catalyst for chemoselective aerobic oxidation of primary alcohols to the aldehydes in the presence of secondary alcohols under ambient and non-irradiated conditions. Complex 3 was also successfully applied to the oxidation of 1-phenyl-1,n-diols to the lactols or the n-hydroxy aldehyde. It is of note that selective oxidation of primary alcohols was achieved even in the presence of activated secondary alcohols.
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U2 - 10.1016/j.tetlet.2009.02.169
DO - 10.1016/j.tetlet.2009.02.169
M3 - Article
AN - SCOPUS:65549166467
VL - 50
SP - 3432
EP - 3435
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 26
ER -