Abstract
Based on the analysis of the mechanism of aerobic oxidation of alcohols using Ru(NO)-salen catalyst, we designed a new complex, Ru(PPh3)(OH)-salen 3, which was proved to be an excellent catalyst for chemoselective aerobic oxidation of primary alcohols to the aldehydes in the presence of secondary alcohols under ambient and non-irradiated conditions. Complex 3 was also successfully applied to the oxidation of 1-phenyl-1,n-diols to the lactols or the n-hydroxy aldehyde. It is of note that selective oxidation of primary alcohols was achieved even in the presence of activated secondary alcohols.
| Original language | English |
|---|---|
| Pages (from-to) | 3432-3435 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 50 |
| Issue number | 26 |
| DOIs | |
| Publication status | Published - Jul 1 2009 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Ru(PPh3)(OH)-salen complex : a designer catalyst for chemoselective aerobic oxidation of primary alcohols. / Mizoguchi, Hirotaka; Uchida, Tatsuya; Ishida, Kohichi; Katsuki, Tsutomu.
In: Tetrahedron Letters, Vol. 50, No. 26, 01.07.2009, p. 3432-3435.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ru(PPh3)(OH)-salen complex
T2 - a designer catalyst for chemoselective aerobic oxidation of primary alcohols
AU - Mizoguchi, Hirotaka
AU - Uchida, Tatsuya
AU - Ishida, Kohichi
AU - Katsuki, Tsutomu
PY - 2009/7/1
Y1 - 2009/7/1
N2 - Based on the analysis of the mechanism of aerobic oxidation of alcohols using Ru(NO)-salen catalyst, we designed a new complex, Ru(PPh3)(OH)-salen 3, which was proved to be an excellent catalyst for chemoselective aerobic oxidation of primary alcohols to the aldehydes in the presence of secondary alcohols under ambient and non-irradiated conditions. Complex 3 was also successfully applied to the oxidation of 1-phenyl-1,n-diols to the lactols or the n-hydroxy aldehyde. It is of note that selective oxidation of primary alcohols was achieved even in the presence of activated secondary alcohols.
AB - Based on the analysis of the mechanism of aerobic oxidation of alcohols using Ru(NO)-salen catalyst, we designed a new complex, Ru(PPh3)(OH)-salen 3, which was proved to be an excellent catalyst for chemoselective aerobic oxidation of primary alcohols to the aldehydes in the presence of secondary alcohols under ambient and non-irradiated conditions. Complex 3 was also successfully applied to the oxidation of 1-phenyl-1,n-diols to the lactols or the n-hydroxy aldehyde. It is of note that selective oxidation of primary alcohols was achieved even in the presence of activated secondary alcohols.
UR - http://www.scopus.com/inward/record.url?scp=65549166467&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65549166467&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2009.02.169
DO - 10.1016/j.tetlet.2009.02.169
M3 - Article
AN - SCOPUS:65549166467
VL - 50
SP - 3432
EP - 3435
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 26
ER -