Abstract
Based on the analysis of the mechanism of aerobic oxidation of alcohols using Ru(NO)-salen catalyst, we designed a new complex, Ru(PPh3)(OH)-salen 3, which was proved to be an excellent catalyst for chemoselective aerobic oxidation of primary alcohols to the aldehydes in the presence of secondary alcohols under ambient and non-irradiated conditions. Complex 3 was also successfully applied to the oxidation of 1-phenyl-1,n-diols to the lactols or the n-hydroxy aldehyde. It is of note that selective oxidation of primary alcohols was achieved even in the presence of activated secondary alcohols.
| Original language | English |
|---|---|
| Pages (from-to) | 3432-3435 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 50 |
| Issue number | 26 |
| DOIs | |
| Publication status | Published - Jul 1 2009 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Mizoguchi, H., Uchida, T., Ishida, K., & Katsuki, T. (2009). Ru(PPh3)(OH)-salen complex: a designer catalyst for chemoselective aerobic oxidation of primary alcohols. Tetrahedron Letters, 50(26), 3432-3435. https://doi.org/10.1016/j.tetlet.2009.02.169