Ruthenium complex-catalyzed anti-Markovnikov hydration of terminal alkynes

Toshiaki Suzuki, Makoto Tokunaga, Yasuo Wakatsuki

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

Highly regioselective, efficient, and substituent-tolerant anti-Markovnikov hydration of terminal alkynes occurs to give n-aldehyde by use of a catalytic amount of easily available cyclopentadienylruthenium complexes bearing appropriate bidentate or monodentate phosphme ligands. Typically, RuCpCl(dppm) (1 mol %) catalyzes the addition of water to 1-hexyne at 100°C to give hexanal in 95% yield: 2-hexanone is not detected at all.

Original languageEnglish
Pages (from-to)735-736
Number of pages2
JournalOrganic Letters
Volume3
Issue number5
DOIs
Publication statusPublished - Mar 8 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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