Abstract
The aim of this study was to clarify the role of serum S100β on the accurate assessment of reversibility of brain damage after fulminant hepatic failure (FHF). Among the 13 patients with FHF enrolled in this study, 12 underwent living donor liver transplantation; one patient could not the procedure because of volvulus of the sigmoid colon. Serum S100β was serially measured using a chemiluminescent immunoassay. Preoperative serum S100β in patients with diffuse brain edema was significantly higher than that in patients with localized brain edema (P < 0.05). Patients with preoperative brain death showed serum S100β levels over 7.0 μg/L. Serum S100β levels correlated with the degree of brain edema of FHF. It has the potential to be a new clinical, noninvasive indicator of brain damage due to FHF.
| Original language | English |
|---|---|
| Pages (from-to) | 2713-2716 |
| Number of pages | 4 |
| Journal | Transplantation Proceedings |
| Volume | 36 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Nov 1 2004 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Transplantation
Cite this
S100β protein : The preoperative new clinical indicator of brain damage in patients with fulminant hepatic failure. / Shiotani, S.; Shimada, M.; Soejima, Y.; Yoshizumi, T.; Uemoto, S.; Kiuchi, T.; Tanaka, K.; Maehara, Y.
In: Transplantation Proceedings, Vol. 36, No. 9, 01.11.2004, p. 2713-2716.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - S100β protein
T2 - The preoperative new clinical indicator of brain damage in patients with fulminant hepatic failure
AU - Shiotani, S.
AU - Shimada, M.
AU - Soejima, Y.
AU - Yoshizumi, T.
AU - Uemoto, S.
AU - Kiuchi, T.
AU - Tanaka, K.
AU - Maehara, Y.
PY - 2004/11/1
Y1 - 2004/11/1
N2 - The aim of this study was to clarify the role of serum S100β on the accurate assessment of reversibility of brain damage after fulminant hepatic failure (FHF). Among the 13 patients with FHF enrolled in this study, 12 underwent living donor liver transplantation; one patient could not the procedure because of volvulus of the sigmoid colon. Serum S100β was serially measured using a chemiluminescent immunoassay. Preoperative serum S100β in patients with diffuse brain edema was significantly higher than that in patients with localized brain edema (P < 0.05). Patients with preoperative brain death showed serum S100β levels over 7.0 μg/L. Serum S100β levels correlated with the degree of brain edema of FHF. It has the potential to be a new clinical, noninvasive indicator of brain damage due to FHF.
AB - The aim of this study was to clarify the role of serum S100β on the accurate assessment of reversibility of brain damage after fulminant hepatic failure (FHF). Among the 13 patients with FHF enrolled in this study, 12 underwent living donor liver transplantation; one patient could not the procedure because of volvulus of the sigmoid colon. Serum S100β was serially measured using a chemiluminescent immunoassay. Preoperative serum S100β in patients with diffuse brain edema was significantly higher than that in patients with localized brain edema (P < 0.05). Patients with preoperative brain death showed serum S100β levels over 7.0 μg/L. Serum S100β levels correlated with the degree of brain edema of FHF. It has the potential to be a new clinical, noninvasive indicator of brain damage due to FHF.
UR - http://www.scopus.com/inward/record.url?scp=11144316843&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11144316843&partnerID=8YFLogxK
U2 - 10.1016/j.transproceed.2004.09.030
DO - 10.1016/j.transproceed.2004.09.030
M3 - Article
C2 - 15621131
AN - SCOPUS:11144316843
VL - 36
SP - 2713
EP - 2716
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 9
ER -