TY - JOUR
T1 - S‐100 protein‐positive dendritic cells in colorectal adenocarcinomas. Distribution and relation to the clinical prognosis
AU - Ambe, Kenji
AU - Mori, Masaki
AU - Enjoji, Munetomo
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1989/2/1
Y1 - 1989/2/1
N2 - Dendritic cells (DC) in 121 colorectal adenocarcinomas were investigated immunohistochemically, using anti‐S‐100 protein antibody. S‐100(+) DC were recognized among the malignant cells and/or around the tumor and differed in distribution either from lysozyme‐positive macrophages or from neuron‐specific enolase‐positive neural tissue. Patients with many S‐100(+) DC (more than 30 cells per 10 high‐power fields) in the tumor survived longer than did those with few such cells (less than 30 cells), most often with no metastases (P < 0.001). The grade of S‐100(+) DC infiltration was related to both density of lymphocytic infiltration in the primary tumor and the degree of paracortical hyperplasia in the regional lymph nodes (P < 0.05). Dendritic cells, therefore, as antigen‐presenting cells, conceivably mediate cell immunity in a tumor with lymphoid infiltration and in the regional lymph nodes. The number of S‐100(+) DC in the primary colorectal carcinomas represents one aspect of such a series of antitumor immunoreaction, in vivo.
AB - Dendritic cells (DC) in 121 colorectal adenocarcinomas were investigated immunohistochemically, using anti‐S‐100 protein antibody. S‐100(+) DC were recognized among the malignant cells and/or around the tumor and differed in distribution either from lysozyme‐positive macrophages or from neuron‐specific enolase‐positive neural tissue. Patients with many S‐100(+) DC (more than 30 cells per 10 high‐power fields) in the tumor survived longer than did those with few such cells (less than 30 cells), most often with no metastases (P < 0.001). The grade of S‐100(+) DC infiltration was related to both density of lymphocytic infiltration in the primary tumor and the degree of paracortical hyperplasia in the regional lymph nodes (P < 0.05). Dendritic cells, therefore, as antigen‐presenting cells, conceivably mediate cell immunity in a tumor with lymphoid infiltration and in the regional lymph nodes. The number of S‐100(+) DC in the primary colorectal carcinomas represents one aspect of such a series of antitumor immunoreaction, in vivo.
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U2 - 10.1002/1097-0142(19890201)63:3<496::AID-CNCR2820630318>3.0.CO;2-K
DO - 10.1002/1097-0142(19890201)63:3<496::AID-CNCR2820630318>3.0.CO;2-K
M3 - Article
C2 - 2912528
AN - SCOPUS:0024548430
VL - 63
SP - 496
EP - 503
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 3
ER -