S100A4 mRNA is a diagnostic and prognostic marker in pancreatic carcinoma

Naoki Ikenaga, Kenoki Ohuchida, Kazuhiro Mizumoto, Jun Yu, Hayato Fujita, Kohei Nakata, Junji Ueda, Norihiro Sato, Eishi Nagai, Masao Tanaka

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective The aim of this study is to evaluate the clinical significance of S100A4 mRNA expression in pancreatic cancer. Materials and Methods We obtained invasive ductal carcinoma (IDC) cells from ten lesions, intraductal papillary mucinous neoplasm (IPMN) cells from 20 lesions, and normal ductal cells from 20 normal pancreatic tissues by laser microdissection of frozen tissues. S100A4 expression was examined in the microdissected cells and in formalin-fixed paraffin-embedded (FFPE) samples of 87 pancreatic cancers by quantitative reverse transcription-polymerase chain reaction. Results IDC cells expressed higher levels of S100A4 than IPMN cells (P = 0.002) and normal ductal cells (P < 0.001), although the difference between IPMN cells and normal ductal cells was not statistically significant (P = 0.070). Analysis of FFPE samples revealed that high S100A4 expression was significantly associated with a shorter overall survival (P = 0.023). In immunohistochemical analysis, the extent of S100A4 mRNA expression was significantly correlated with the expression of S100A4 protein (P = 0.028). Conclusion S100A4 could be a marker for malignancy in pancreatic tumors and for poor prognosis in patients with pancreatic cancer.

Original languageEnglish
Pages (from-to)1852-1858
Number of pages7
JournalJournal of Gastrointestinal Surgery
Volume13
Issue number10
DOIs
Publication statusPublished - Sep 2009

All Science Journal Classification (ASJC) codes

  • Surgery
  • Gastroenterology

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