Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

Shan Lu; Shinichi Nishimura; Go Hirai; Masashi Ito; Teppei Kawahara; Miho Izumikawa; Mikiko Sodeoka; Kazuo Shin-Ya; Toshio Tsuchida; Hideaki Kakeya

doi:10.1039/c5cc01953b

Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

Shan Lu, Shinichi Nishimura, Go Hirai, Masashi Ito, Teppei Kawahara, Miho Izumikawa, Mikiko Sodeoka, Kazuo Shin-Ya, Toshio Tsuchida, Hideaki Kakeya

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp³ carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.

Original language	English
Pages (from-to)	8074-8077
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	38
DOIs	https://doi.org/10.1039/c5cc01953b
Publication status	Published - May 11 2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c5cc01953b

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title = "Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.",

abstract = "Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp3 carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.",

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day = "11",

doi = "10.1039/c5cc01953b",

language = "English",

volume = "51",

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journal = "Chemical Communications",

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T1 - Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

AU - Lu, Shan

AU - Nishimura, Shinichi

AU - Hirai, Go

AU - Ito, Masashi

AU - Kawahara, Teppei

AU - Izumikawa, Miho

AU - Sodeoka, Mikiko

AU - Shin-Ya, Kazuo

AU - Tsuchida, Toshio

AU - Kakeya, Hideaki

PY - 2015/5/11

Y1 - 2015/5/11

N2 - Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp3 carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.

AB - Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp3 carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

Abstract

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