Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

Shan Lu, Shinichi Nishimura, Go Hirai, Masashi Ito, Teppei Kawahara, Miho Izumikawa, Mikiko Sodeoka, Kazuo Shin-Ya, Toshio Tsuchida, Hideaki Kakeya

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp3 carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.

Original languageEnglish
Pages (from-to)8074-8077
Number of pages4
JournalChemical Communications
Volume51
Issue number38
DOIs
Publication statusPublished - May 11 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.'. Together they form a unique fingerprint.

Cite this