Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

Shan Lu, Shinichi Nishimura, Go Hirai, Masashi Ito, Teppei Kawahara, Miho Izumikawa, Mikiko Sodeoka, Kazuo Shin-Ya, Toshio Tsuchida, Hideaki Kakeya

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp3 carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.

Original languageEnglish
Pages (from-to)8074-8077
Number of pages4
JournalChemical Communications
Volume51
Issue number38
DOIs
Publication statusPublished - May 11 2015
Externally publishedYes

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Spectroscopic analysis
Chirality
Macrolides
Cytotoxicity
Tumors
Carbon
Cells
saccharothriolide B

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp. / Lu, Shan; Nishimura, Shinichi; Hirai, Go; Ito, Masashi; Kawahara, Teppei; Izumikawa, Miho; Sodeoka, Mikiko; Shin-Ya, Kazuo; Tsuchida, Toshio; Kakeya, Hideaki.

In: Chemical Communications, Vol. 51, No. 38, 11.05.2015, p. 8074-8077.

Research output: Contribution to journalArticle

Lu, S, Nishimura, S, Hirai, G, Ito, M, Kawahara, T, Izumikawa, M, Sodeoka, M, Shin-Ya, K, Tsuchida, T & Kakeya, H 2015, 'Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.', Chemical Communications, vol. 51, no. 38, pp. 8074-8077. https://doi.org/10.1039/c5cc01953b
Lu, Shan ; Nishimura, Shinichi ; Hirai, Go ; Ito, Masashi ; Kawahara, Teppei ; Izumikawa, Miho ; Sodeoka, Mikiko ; Shin-Ya, Kazuo ; Tsuchida, Toshio ; Kakeya, Hideaki. / Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp. In: Chemical Communications. 2015 ; Vol. 51, No. 38. pp. 8074-8077.
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AU - Kawahara, Teppei

AU - Izumikawa, Miho

AU - Sodeoka, Mikiko

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AU - Tsuchida, Toshio

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