Safety and efficacy of an “enhanced recovery after surgery” protocol for patients undergoing colon cancer surgery: a multi-institutional controlled study

Hirofumi Ota, Masakazu Ikenaga, Junichi Hasegawa, Kohei Murata, Yasuhiro Miyake, Tsunekazu Mizushima, Taishi Hata, Ichiro Takemasa, Hirofumi Yamamoto, Mitsugu Sekimoto, Riichiro Nezu, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Purpose: The aim of this multi-institutional study was to prospectively evaluate the safety and efficacy of an enhanced recovery after surgery (ERAS) protocol for colonic surgery. Methods: The subjects of this study were 320 patients with an American Society of Anesthesiologists (ASA) grade I or II physical status. Patients underwent elective open or laparoscopic colonic resection or high anterior resection between April 2011 and January 2014 at one of six institutions. Three hospitals implemented an ERAS protocol (n = 159), and three administered conventional care (n = 161). The primary outcome measure was the surgical complication rate. Results: Most operations, irrespective of group, were performed laparoscopically. The incidence of a surgical complication was 17.0 % in the ERAS group vs. 16.1 % in the conventional group (P = 0.842), in which several non-surgical complications also arose. Oral food intake was implemented earlier for the ERAS group vs. the conventional group, after a median (range) of 1 (1–31) vs. 3 (1–9) days for the ERAS vs. conventional care groups, respectively (P < 0.001). The median length of postoperative hospital stay was reduced by 5.5 days for the ERAS group, being 8.5 (5–41) vs. 14 (7–56) days for the ERAS vs. conventional care groups, respectively (P < 0.001). Conclusion: This multi-institutional controlled study clearly demonstrated that an ERAS protocol was efficient, without increasing the complication risk.

Original languageEnglish
Pages (from-to)668-675
Number of pages8
JournalSurgery today
Volume47
Issue number6
DOIs
Publication statusPublished - Jun 1 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery

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