Safety and Efficacy of Benzalkonium Chloride-optimized Tafluprost in Japanese Glaucoma Patients with Existing Superficial Punctate Keratitis

Katsuyoshi Suzuki, Shinichiro Teranishi, Takeshi Sagara, Hideaki Yoshino, Masako Nakayama, Miho Enoki, Yoshihisa Nuno, Shinji Hirano, Makiko Wakuta, Norihisa Takahashi, Kayoko Tokuhisa, Yukiko Kondo, Rie Shiraishi, Yasuhito Ishida, Koh Hei Sonoda

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9 Citations (Scopus)

Abstract

Purpose: To evaluate the safety and efficacy of benzalkonium chloride (BAK)-optimized tafluprost (with a BAK concentration reduced from 0.01% to 0.001%) in glaucoma patients with existing superficial punctate keratitis (SPK). Patients and Methods: A prospective, multicenter, open-label study was designed to compare BAK-optimized tafluprost administered over 12 weeks relative to other preserved prostaglandin analogs previously administered in Japanese glaucoma patients. Thirty patients with SPK graded at <6 points by area density (AD) scoring in 1 eye were recruited. The primary outcome measure was change in AD score at 12 weeks after the switch in treatment compared with that at baseline. Secondary outcome measures included changes in tear film breakup time (TBUT), hyperemia score, and intraocular pressure (IOP). Four patients were excluded from analysis because of treatment discontinuation. Results: Mean AD score±SD decreased significantly from 3.4±0.9 to 1.8±1.8 after the switch (P<0.0001). Mean TBUT increased significantly from 6.3±3.3 to 8.0±4.2 seconds (P<0.01). Mean hyperemia score remained unchanged, whereas mean IOP decreased significantly from 15.6±2.6 to 14.4±2.0 mm Hg (P<0.01). For patients previously treated with BAK-preserved latanoprost (n=17) or bimatoprost (n=2), mean AD score decreased significantly from 3.4±0.9 to 1.8±1.8 (P<0.01) and mean TBUT increased significantly from 6.4±3.6 to 8.2±4.3 seconds (P<0.01); no such changes were apparent for patients previously treated with sofZia-preserved travoprost (n=7). Conclusions: BAK-optimized tafluprost is a treatment option to improve the condition of the ocular surface and to maintain IOP control in glaucoma patients with existing SPK who have been previously treated with other BAK-preserved prostaglandin analogs.

Original languageEnglish
Pages (from-to)e145-e150
JournalJournal of Glaucoma
Volume24
Issue number6
DOIs
Publication statusPublished - Aug 19 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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