Safety evaluation of wood-based activated carbon fibers in a 28-day feeding study in Sprague-Dawley rats

Han Chien Lin, Ji Cheng Hsueh, Wen Ru Li, Ying Jang Lai, She Ching Wu, Noboru Fujimoto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

As a possible food moisture-proof material, wood-based activated carbon fibers (WACFs), prepared from one type of wood pulp: Laubholz Unbleached Kraft Pulp (LUKP) by the physical activation method with steam at an 850°C activation temperature with 60 min of activation time (850 LUKP WACFs), were evaluated in a 28-day feeding study of Sprague-Dawley rats (SD rats) after the Ames test had been carried out in a previous paper. SD rats were randomly distributed into five groups, including a blank group (reverse osmosis water), a control group (saline), and groups with low, moderate, and high (1.0, 2.5, and 5.0 g/kg/day, respectively) doses of 850 LUKP WACFs. All SD rats were sacrificed after a 28-day feeding toxicity study. Blood samples were analyzed for hematological and serum biochemical values, and histopathological examinations of the organs were investigated. There were insignificant differences from the clinical pathology; that is, no observable adverse effect levels (NOAEL) of 850 LUKP WACFs greater than 5.0g/kg/day. It is suggested that WACFs prepared from wood pulp can be a potential type of food moisture-proof material and a potential type of material for water quality improvement due to their biological safety results.

Original languageEnglish
Pages (from-to)427-434
Number of pages8
JournalJournal of the Faculty of Agriculture, Kyushu University
Volume60
Issue number2
Publication statusPublished - Sep 1 2015

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activated carbon
kraft pulp
Sprague Dawley Rats
pulpwood
Safety
wood pulp
rats
reverse osmosis
Ames test
toxicity testing
blood serum
Osmosis
steam
Food
Clinical Pathology
Water Quality
Steam
water quality
adverse effects
Quality Improvement

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Agronomy and Crop Science

Cite this

Safety evaluation of wood-based activated carbon fibers in a 28-day feeding study in Sprague-Dawley rats. / Lin, Han Chien; Hsueh, Ji Cheng; Li, Wen Ru; Lai, Ying Jang; Wu, She Ching; Fujimoto, Noboru.

In: Journal of the Faculty of Agriculture, Kyushu University, Vol. 60, No. 2, 01.09.2015, p. 427-434.

Research output: Contribution to journalArticle

Lin, Han Chien ; Hsueh, Ji Cheng ; Li, Wen Ru ; Lai, Ying Jang ; Wu, She Ching ; Fujimoto, Noboru. / Safety evaluation of wood-based activated carbon fibers in a 28-day feeding study in Sprague-Dawley rats. In: Journal of the Faculty of Agriculture, Kyushu University. 2015 ; Vol. 60, No. 2. pp. 427-434.
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