Safety of Garcinia cambogia Extract in Healthy Men: High-Doses Administration Study I

Kohsuke Hayamizu; Yuri Ishii; Norihiro Shigematsu; Yasuhide Okuhara; Hironori Tomi; Mitsuhiro Furuse; Gen Yoshino; Hiroyuki Shimasaki

doi:10.5650/jos.52.499

Safety of Garcinia cambogia Extract in Healthy Men: High-Doses Administration Study I

Kohsuke Hayamizu, Yuri Ishii, Norihiro Shigematsu, Yasuhide Okuhara, Hironori Tomi, Mitsuhiro Furuse, Gen Yoshino, Hiroyuki Shimasaki

Animal and Marine Bioresource Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

(—)-Hydroxycitric acid (HCA), a competitive inhibitor of ATP-citrate lyase, is frequently used in dietary supplements for weight loss. Recently, it was reported in a 52w toxicity study that Garcinia extract powder induced testicular atrophy in rats. In order to study the safety, Garcinia extract was administered to 10 healthy adult men at dose of 3, 000 mg/day as HCA for 30 days. No toxicological changes were observed on anthropometric indices or clinical analysis. In addition, serum testosterone showed no change throughout the test period. In regard to subjective symptoms, very slight anorexia (two cases) and headache (one case) occurred. Therefore, we consider that Garcinia extract is safe as administered under the condition of this study.

Original language	English
Pages (from-to)	499-504
Number of pages	6
Journal	Journal of oleo science
Volume	52
Issue number	9
DOIs	https://doi.org/10.5650/jos.52.499
Publication status	Published - 2003

All Science Journal Classification (ASJC) codes

Chemistry(all)
Chemical Engineering(all)

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title = "Safety of Garcinia cambogia Extract in Healthy Men: High-Doses Administration Study I",

abstract = "(—)-Hydroxycitric acid (HCA), a competitive inhibitor of ATP-citrate lyase, is frequently used in dietary supplements for weight loss. Recently, it was reported in a 52w toxicity study that Garcinia extract powder induced testicular atrophy in rats. In order to study the safety, Garcinia extract was administered to 10 healthy adult men at dose of 3, 000 mg/day as HCA for 30 days. No toxicological changes were observed on anthropometric indices or clinical analysis. In addition, serum testosterone showed no change throughout the test period. In regard to subjective symptoms, very slight anorexia (two cases) and headache (one case) occurred. Therefore, we consider that Garcinia extract is safe as administered under the condition of this study.",

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T1 - Safety of Garcinia cambogia Extract in Healthy Men

T2 - High-Doses Administration Study I

AU - Hayamizu, Kohsuke

AU - Ishii, Yuri

AU - Shigematsu, Norihiro

AU - Okuhara, Yasuhide

AU - Tomi, Hironori

AU - Furuse, Mitsuhiro

AU - Yoshino, Gen

AU - Shimasaki, Hiroyuki

PY - 2003

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