TY - JOUR
T1 - Safety of Garcinia cambogia Extract in Healthy Men
T2 - High-Doses Administration Study I
AU - Hayamizu, Kohsuke
AU - Ishii, Yuri
AU - Shigematsu, Norihiro
AU - Okuhara, Yasuhide
AU - Tomi, Hironori
AU - Furuse, Mitsuhiro
AU - Yoshino, Gen
AU - Shimasaki, Hiroyuki
PY - 2003
Y1 - 2003
N2 - (—)-Hydroxycitric acid (HCA), a competitive inhibitor of ATP-citrate lyase, is frequently used in dietary supplements for weight loss. Recently, it was reported in a 52w toxicity study that Garcinia extract powder induced testicular atrophy in rats. In order to study the safety, Garcinia extract was administered to 10 healthy adult men at dose of 3, 000 mg/day as HCA for 30 days. No toxicological changes were observed on anthropometric indices or clinical analysis. In addition, serum testosterone showed no change throughout the test period. In regard to subjective symptoms, very slight anorexia (two cases) and headache (one case) occurred. Therefore, we consider that Garcinia extract is safe as administered under the condition of this study.
AB - (—)-Hydroxycitric acid (HCA), a competitive inhibitor of ATP-citrate lyase, is frequently used in dietary supplements for weight loss. Recently, it was reported in a 52w toxicity study that Garcinia extract powder induced testicular atrophy in rats. In order to study the safety, Garcinia extract was administered to 10 healthy adult men at dose of 3, 000 mg/day as HCA for 30 days. No toxicological changes were observed on anthropometric indices or clinical analysis. In addition, serum testosterone showed no change throughout the test period. In regard to subjective symptoms, very slight anorexia (two cases) and headache (one case) occurred. Therefore, we consider that Garcinia extract is safe as administered under the condition of this study.
UR - http://www.scopus.com/inward/record.url?scp=33644646273&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33644646273&partnerID=8YFLogxK
U2 - 10.5650/jos.52.499
DO - 10.5650/jos.52.499
M3 - Article
AN - SCOPUS:33644646273
VL - 52
SP - 499
EP - 504
JO - Journal of Oleo Science
JF - Journal of Oleo Science
SN - 1345-8957
IS - 9
ER -