Safflower leaf ameliorates cognitive impairment through moderating excessive astrocyte activation in APP/PS1 mice

Tiantian Zhang, Shuangxi Zhang, Yunhua Peng, Yongyao Wang, Peipei Gao, Yachong Hu, Zhen Wang, Mami Noda, Midori Hiramatsu, Jiankang Liu, Jiangang Long

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

In addition to beta-amyloid (Aβ) plaques and neurofibrillary tangles, Alzheimer's disease (AD) is typically triggered or accompanied by abnormal inflammation, oxidative stress and astrocyte activation. Safflower (Carthamus tinctorius L.) leaf, featuring functional ingredients, is a commonly consumed leafy vegetable. Whether and how dietary safflower leaf powder (SLP) ameliorates cognitive function in an AD mouse model has remained minimally explored. Therefore, we orally administered SLP to APP/PS1 transgenic mice to explore the neuroprotective effects of SLP in preventing AD progression. We found that SLP markedly improved cognitive impairment in APP/PS1 mice, as indicated by the water maze test. We further demonstrated that SLP treatment ameliorated inflammation, oxidative stress and excessive astrocyte activation. Further investigation indicated that SLP decreased the Aβ burden in APP/PS1 mice by mediating excessive astrocyte activation. Our study suggests that safflower leaf is possibly a promising, cognitively beneficial food for preventing and alleviating AD-related dementia.

Original languageEnglish
Pages (from-to)11704-11716
Number of pages13
JournalFood and Function
Volume12
Issue number22
DOIs
Publication statusPublished - Nov 21 2021

All Science Journal Classification (ASJC) codes

  • Food Science

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