Abstract
A 22-year-old woman with ulcerative colitis developed skin eruptions, liver dysfunction, and atypical lymphocytes in the peripheral blood two weeks after she started taking salazosulfapyridine (SASP). Skin eruptions and liver damage were severe. Drug-induced lymphocyte stimulation test (DLST) for SASP was positive. She was diagnosed as having SASP-induced hypersensitivity syndrome (HS). Corticosteroid therapy was needed to suppress these reactions. The transient elevation of HHV-6 IgG titer paralleled the symptoms, which indicated that these reactions were associated with the reactivation of HHV-6. We suggest that HHV-6 IgG titer is one of the modalities for the diagnosis and the prediction of the clinical course of HS.
| Original language | English |
|---|---|
| Pages (from-to) | 203-207 |
| Number of pages | 5 |
| Journal | Internal Medicine |
| Volume | 42 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2003 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
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Salazosulfapyridine induced hypersensitivity syndrome associated with reactivation of humanherpes virus 6. / Kunisaki, Yuya; Goto, Hiroshi; Kitagawa, Kikuo; Nagano, Masanori.
In: Internal Medicine, Vol. 42, No. 2, 01.02.2003, p. 203-207.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Salazosulfapyridine induced hypersensitivity syndrome associated with reactivation of humanherpes virus 6
AU - Kunisaki, Yuya
AU - Goto, Hiroshi
AU - Kitagawa, Kikuo
AU - Nagano, Masanori
PY - 2003/2/1
Y1 - 2003/2/1
N2 - A 22-year-old woman with ulcerative colitis developed skin eruptions, liver dysfunction, and atypical lymphocytes in the peripheral blood two weeks after she started taking salazosulfapyridine (SASP). Skin eruptions and liver damage were severe. Drug-induced lymphocyte stimulation test (DLST) for SASP was positive. She was diagnosed as having SASP-induced hypersensitivity syndrome (HS). Corticosteroid therapy was needed to suppress these reactions. The transient elevation of HHV-6 IgG titer paralleled the symptoms, which indicated that these reactions were associated with the reactivation of HHV-6. We suggest that HHV-6 IgG titer is one of the modalities for the diagnosis and the prediction of the clinical course of HS.
AB - A 22-year-old woman with ulcerative colitis developed skin eruptions, liver dysfunction, and atypical lymphocytes in the peripheral blood two weeks after she started taking salazosulfapyridine (SASP). Skin eruptions and liver damage were severe. Drug-induced lymphocyte stimulation test (DLST) for SASP was positive. She was diagnosed as having SASP-induced hypersensitivity syndrome (HS). Corticosteroid therapy was needed to suppress these reactions. The transient elevation of HHV-6 IgG titer paralleled the symptoms, which indicated that these reactions were associated with the reactivation of HHV-6. We suggest that HHV-6 IgG titer is one of the modalities for the diagnosis and the prediction of the clinical course of HS.
UR - http://www.scopus.com/inward/record.url?scp=0345421269&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345421269&partnerID=8YFLogxK
U2 - 10.2169/internalmedicine.42.203
DO - 10.2169/internalmedicine.42.203
M3 - Article
C2 - 12636244
AN - SCOPUS:0345421269
VL - 42
SP - 203
EP - 207
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 2
ER -