Abstract
PURPOSE: To evaluate the diagnostic value of gadolinium-enhanced dynamic magnetic resonance (MR) imaging of salivary gland tumors and correlate the MR imaging and histopathologic findings. MATERIALS AND METHODS: Thirty-three salivary gland tumors in 29 patients were examined preoperatively at gadolinium-enhanced dynamic MR imaging. There were 22 benign and 11 malignant tumors. Dynamic contrast material-enhanced MR images were obtained for 5 minutes. Time of peak enhancement (Tpeak) and washout ratio (WR) were determined from time-signal intensity curves (TICs). Microvessel count and cellularity-stromal grade were evaluated histopathologically. The strengths of correlations between Tpeak and microvessel count and between WR and cellularity-stromal grade were statistically analyzed to determine whether any differences among the various histopathologic tumor types existed. In a validation study, 13 salivary gland tumors in 13 patients were examined consecutively. RESULTS: At a Tpeak of 120 seconds, malignant tumors could be differentiated from pleomorphic adenomas but not from Warthin tumors. A WR of 30%, however, enabled differentiation between malignant and Warthin tumors. Classification of TICs on the basis of a Tpeak of 120 seconds and a WR of 30% had high sensitivity (91%) and specificity (91%) in the differentiation of benign and malignant tumors. Correlations between Tpeak and microvessel count (P < .0001, p = -0.800) and between WR and cellularity-stromal grade (P = .0105, p = 0.572) were significant. The validation study also yielded high sensitivity (100%) and specificity (80%) in the differentiation between benign and malignant tumors. CONCLUSION: Gadolinium-enhanced dynamic MR imaging is useful for differentiating benign from malignant salivary gland tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 345-354 |
| Number of pages | 10 |
| Journal | Radiology |
| Volume | 226 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2003 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
Cite this
Salivary gland tumors : Diagnostic value of gadolinium-enhanced dynamic MR imaging with histopathologic correlation. / Yabuuchi, Hidetake; Fukuya, Tatsuro; Tajima, Tsuyoshi; Hachitanda, Yoichi; Tomita, Kichinobu; Koga, Mitsuru.
In: Radiology, Vol. 226, No. 2, 01.02.2003, p. 345-354.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Salivary gland tumors
T2 - Diagnostic value of gadolinium-enhanced dynamic MR imaging with histopathologic correlation
AU - Yabuuchi, Hidetake
AU - Fukuya, Tatsuro
AU - Tajima, Tsuyoshi
AU - Hachitanda, Yoichi
AU - Tomita, Kichinobu
AU - Koga, Mitsuru
PY - 2003/2/1
Y1 - 2003/2/1
N2 - PURPOSE: To evaluate the diagnostic value of gadolinium-enhanced dynamic magnetic resonance (MR) imaging of salivary gland tumors and correlate the MR imaging and histopathologic findings. MATERIALS AND METHODS: Thirty-three salivary gland tumors in 29 patients were examined preoperatively at gadolinium-enhanced dynamic MR imaging. There were 22 benign and 11 malignant tumors. Dynamic contrast material-enhanced MR images were obtained for 5 minutes. Time of peak enhancement (Tpeak) and washout ratio (WR) were determined from time-signal intensity curves (TICs). Microvessel count and cellularity-stromal grade were evaluated histopathologically. The strengths of correlations between Tpeak and microvessel count and between WR and cellularity-stromal grade were statistically analyzed to determine whether any differences among the various histopathologic tumor types existed. In a validation study, 13 salivary gland tumors in 13 patients were examined consecutively. RESULTS: At a Tpeak of 120 seconds, malignant tumors could be differentiated from pleomorphic adenomas but not from Warthin tumors. A WR of 30%, however, enabled differentiation between malignant and Warthin tumors. Classification of TICs on the basis of a Tpeak of 120 seconds and a WR of 30% had high sensitivity (91%) and specificity (91%) in the differentiation of benign and malignant tumors. Correlations between Tpeak and microvessel count (P < .0001, p = -0.800) and between WR and cellularity-stromal grade (P = .0105, p = 0.572) were significant. The validation study also yielded high sensitivity (100%) and specificity (80%) in the differentiation between benign and malignant tumors. CONCLUSION: Gadolinium-enhanced dynamic MR imaging is useful for differentiating benign from malignant salivary gland tumors.
AB - PURPOSE: To evaluate the diagnostic value of gadolinium-enhanced dynamic magnetic resonance (MR) imaging of salivary gland tumors and correlate the MR imaging and histopathologic findings. MATERIALS AND METHODS: Thirty-three salivary gland tumors in 29 patients were examined preoperatively at gadolinium-enhanced dynamic MR imaging. There were 22 benign and 11 malignant tumors. Dynamic contrast material-enhanced MR images were obtained for 5 minutes. Time of peak enhancement (Tpeak) and washout ratio (WR) were determined from time-signal intensity curves (TICs). Microvessel count and cellularity-stromal grade were evaluated histopathologically. The strengths of correlations between Tpeak and microvessel count and between WR and cellularity-stromal grade were statistically analyzed to determine whether any differences among the various histopathologic tumor types existed. In a validation study, 13 salivary gland tumors in 13 patients were examined consecutively. RESULTS: At a Tpeak of 120 seconds, malignant tumors could be differentiated from pleomorphic adenomas but not from Warthin tumors. A WR of 30%, however, enabled differentiation between malignant and Warthin tumors. Classification of TICs on the basis of a Tpeak of 120 seconds and a WR of 30% had high sensitivity (91%) and specificity (91%) in the differentiation of benign and malignant tumors. Correlations between Tpeak and microvessel count (P < .0001, p = -0.800) and between WR and cellularity-stromal grade (P = .0105, p = 0.572) were significant. The validation study also yielded high sensitivity (100%) and specificity (80%) in the differentiation between benign and malignant tumors. CONCLUSION: Gadolinium-enhanced dynamic MR imaging is useful for differentiating benign from malignant salivary gland tumors.
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UR - http://www.scopus.com/inward/citedby.url?scp=0037295180&partnerID=8YFLogxK
U2 - 10.1148/radiol.2262011486
DO - 10.1148/radiol.2262011486
M3 - Article
C2 - 12563124
AN - SCOPUS:0037295180
VL - 226
SP - 345
EP - 354
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 2
ER -