Salivary gland tumors: Diagnostic value of gadolinium-enhanced dynamic MR imaging with histopathologic correlation

Hidetake Yabuuchi, Tatsuro Fukuya, Tsuyoshi Tajima, Yoichi Hachitanda, Kichinobu Tomita, Mitsuru Koga

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To evaluate the diagnostic value of gadolinium-enhanced dynamic magnetic resonance (MR) imaging of salivary gland tumors and correlate the MR imaging and histopathologic findings. MATERIALS AND METHODS: Thirty-three salivary gland tumors in 29 patients were examined preoperatively at gadolinium-enhanced dynamic MR imaging. There were 22 benign and 11 malignant tumors. Dynamic contrast material-enhanced MR images were obtained for 5 minutes. Time of peak enhancement (Tpeak) and washout ratio (WR) were determined from time-signal intensity curves (TICs). Microvessel count and cellularity-stromal grade were evaluated histopathologically. The strengths of correlations between Tpeak and microvessel count and between WR and cellularity-stromal grade were statistically analyzed to determine whether any differences among the various histopathologic tumor types existed. In a validation study, 13 salivary gland tumors in 13 patients were examined consecutively. RESULTS: At a Tpeak of 120 seconds, malignant tumors could be differentiated from pleomorphic adenomas but not from Warthin tumors. A WR of 30%, however, enabled differentiation between malignant and Warthin tumors. Classification of TICs on the basis of a Tpeak of 120 seconds and a WR of 30% had high sensitivity (91%) and specificity (91%) in the differentiation of benign and malignant tumors. Correlations between Tpeak and microvessel count (P < .0001, p = -0.800) and between WR and cellularity-stromal grade (P = .0105, p = 0.572) were significant. The validation study also yielded high sensitivity (100%) and specificity (80%) in the differentiation between benign and malignant tumors. CONCLUSION: Gadolinium-enhanced dynamic MR imaging is useful for differentiating benign from malignant salivary gland tumors.

Original languageEnglish
Pages (from-to)345-354
Number of pages10
JournalRadiology
Volume226
Issue number2
DOIs
Publication statusPublished - Feb 1 2003
Externally publishedYes

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Glandular and Epithelial Neoplasms
Gadolinium
Magnetic Resonance Imaging
Microvessels
Adenolymphoma
Validation Studies
Neoplasms
Sensitivity and Specificity
Pleomorphic Adenoma
Contrast Media
Magnetic Resonance Spectroscopy

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Salivary gland tumors : Diagnostic value of gadolinium-enhanced dynamic MR imaging with histopathologic correlation. / Yabuuchi, Hidetake; Fukuya, Tatsuro; Tajima, Tsuyoshi; Hachitanda, Yoichi; Tomita, Kichinobu; Koga, Mitsuru.

In: Radiology, Vol. 226, No. 2, 01.02.2003, p. 345-354.

Research output: Contribution to journalArticle

Yabuuchi, Hidetake ; Fukuya, Tatsuro ; Tajima, Tsuyoshi ; Hachitanda, Yoichi ; Tomita, Kichinobu ; Koga, Mitsuru. / Salivary gland tumors : Diagnostic value of gadolinium-enhanced dynamic MR imaging with histopathologic correlation. In: Radiology. 2003 ; Vol. 226, No. 2. pp. 345-354.
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abstract = "PURPOSE: To evaluate the diagnostic value of gadolinium-enhanced dynamic magnetic resonance (MR) imaging of salivary gland tumors and correlate the MR imaging and histopathologic findings. MATERIALS AND METHODS: Thirty-three salivary gland tumors in 29 patients were examined preoperatively at gadolinium-enhanced dynamic MR imaging. There were 22 benign and 11 malignant tumors. Dynamic contrast material-enhanced MR images were obtained for 5 minutes. Time of peak enhancement (Tpeak) and washout ratio (WR) were determined from time-signal intensity curves (TICs). Microvessel count and cellularity-stromal grade were evaluated histopathologically. The strengths of correlations between Tpeak and microvessel count and between WR and cellularity-stromal grade were statistically analyzed to determine whether any differences among the various histopathologic tumor types existed. In a validation study, 13 salivary gland tumors in 13 patients were examined consecutively. RESULTS: At a Tpeak of 120 seconds, malignant tumors could be differentiated from pleomorphic adenomas but not from Warthin tumors. A WR of 30{\%}, however, enabled differentiation between malignant and Warthin tumors. Classification of TICs on the basis of a Tpeak of 120 seconds and a WR of 30{\%} had high sensitivity (91{\%}) and specificity (91{\%}) in the differentiation of benign and malignant tumors. Correlations between Tpeak and microvessel count (P < .0001, p = -0.800) and between WR and cellularity-stromal grade (P = .0105, p = 0.572) were significant. The validation study also yielded high sensitivity (100{\%}) and specificity (80{\%}) in the differentiation between benign and malignant tumors. CONCLUSION: Gadolinium-enhanced dynamic MR imaging is useful for differentiating benign from malignant salivary gland tumors.",
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N2 - PURPOSE: To evaluate the diagnostic value of gadolinium-enhanced dynamic magnetic resonance (MR) imaging of salivary gland tumors and correlate the MR imaging and histopathologic findings. MATERIALS AND METHODS: Thirty-three salivary gland tumors in 29 patients were examined preoperatively at gadolinium-enhanced dynamic MR imaging. There were 22 benign and 11 malignant tumors. Dynamic contrast material-enhanced MR images were obtained for 5 minutes. Time of peak enhancement (Tpeak) and washout ratio (WR) were determined from time-signal intensity curves (TICs). Microvessel count and cellularity-stromal grade were evaluated histopathologically. The strengths of correlations between Tpeak and microvessel count and between WR and cellularity-stromal grade were statistically analyzed to determine whether any differences among the various histopathologic tumor types existed. In a validation study, 13 salivary gland tumors in 13 patients were examined consecutively. RESULTS: At a Tpeak of 120 seconds, malignant tumors could be differentiated from pleomorphic adenomas but not from Warthin tumors. A WR of 30%, however, enabled differentiation between malignant and Warthin tumors. Classification of TICs on the basis of a Tpeak of 120 seconds and a WR of 30% had high sensitivity (91%) and specificity (91%) in the differentiation of benign and malignant tumors. Correlations between Tpeak and microvessel count (P < .0001, p = -0.800) and between WR and cellularity-stromal grade (P = .0105, p = 0.572) were significant. The validation study also yielded high sensitivity (100%) and specificity (80%) in the differentiation between benign and malignant tumors. CONCLUSION: Gadolinium-enhanced dynamic MR imaging is useful for differentiating benign from malignant salivary gland tumors.

AB - PURPOSE: To evaluate the diagnostic value of gadolinium-enhanced dynamic magnetic resonance (MR) imaging of salivary gland tumors and correlate the MR imaging and histopathologic findings. MATERIALS AND METHODS: Thirty-three salivary gland tumors in 29 patients were examined preoperatively at gadolinium-enhanced dynamic MR imaging. There were 22 benign and 11 malignant tumors. Dynamic contrast material-enhanced MR images were obtained for 5 minutes. Time of peak enhancement (Tpeak) and washout ratio (WR) were determined from time-signal intensity curves (TICs). Microvessel count and cellularity-stromal grade were evaluated histopathologically. The strengths of correlations between Tpeak and microvessel count and between WR and cellularity-stromal grade were statistically analyzed to determine whether any differences among the various histopathologic tumor types existed. In a validation study, 13 salivary gland tumors in 13 patients were examined consecutively. RESULTS: At a Tpeak of 120 seconds, malignant tumors could be differentiated from pleomorphic adenomas but not from Warthin tumors. A WR of 30%, however, enabled differentiation between malignant and Warthin tumors. Classification of TICs on the basis of a Tpeak of 120 seconds and a WR of 30% had high sensitivity (91%) and specificity (91%) in the differentiation of benign and malignant tumors. Correlations between Tpeak and microvessel count (P < .0001, p = -0.800) and between WR and cellularity-stromal grade (P = .0105, p = 0.572) were significant. The validation study also yielded high sensitivity (100%) and specificity (80%) in the differentiation between benign and malignant tumors. CONCLUSION: Gadolinium-enhanced dynamic MR imaging is useful for differentiating benign from malignant salivary gland tumors.

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