Saposin D: a sphingomyelinase activator

S Morimoto, B M Martin, Y Kishimoto, J S O'Brien

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Saposin D, a newly discovered heat-stable, 10 kDa glycoprotein, was isolated from Gaucher spleen and purified to homogeneity. Chemical sequencing from its amino terminus demonstrated colinearity between its amino acid sequence and the deduced amino acid sequence of the fourth domain of prosaposin, the precursor of saposin proteins. Saposin D specifically stimulates acid sphingomyelinase but has no significant effect on the other hydrolases tested.

Original languageEnglish
Pages (from-to)403-10
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume156
Issue number1
Publication statusPublished - Oct 14 1988

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Saposins
Sphingomyelin Phosphodiesterase
Amino Acid Sequence
Amino Acids
Protein Precursors
Hydrolases
Glycoproteins
Spleen
Hot Temperature
Acids
Proteins

Cite this

Morimoto, S., Martin, B. M., Kishimoto, Y., & O'Brien, J. S. (1988). Saposin D: a sphingomyelinase activator. Biochemical and Biophysical Research Communications, 156(1), 403-10.

Saposin D : a sphingomyelinase activator. / Morimoto, S; Martin, B M; Kishimoto, Y; O'Brien, J S.

In: Biochemical and Biophysical Research Communications, Vol. 156, No. 1, 14.10.1988, p. 403-10.

Research output: Contribution to journalArticle

Morimoto, S, Martin, BM, Kishimoto, Y & O'Brien, JS 1988, 'Saposin D: a sphingomyelinase activator', Biochemical and Biophysical Research Communications, vol. 156, no. 1, pp. 403-10.
Morimoto S, Martin BM, Kishimoto Y, O'Brien JS. Saposin D: a sphingomyelinase activator. Biochemical and Biophysical Research Communications. 1988 Oct 14;156(1):403-10.
Morimoto, S ; Martin, B M ; Kishimoto, Y ; O'Brien, J S. / Saposin D : a sphingomyelinase activator. In: Biochemical and Biophysical Research Communications. 1988 ; Vol. 156, No. 1. pp. 403-10.
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