TY - JOUR
T1 - Sarcomatous hepatocellular carcinoma
T2 - A special reference to ordinary hepatocellular carcinoma
AU - Nishi, Hidehiro
AU - Taguchi, Ken Ichi
AU - Asayama, Yoshiki
AU - Aishima, Shin Ichi
AU - Sugimachi, Keishi
AU - Nawata, Hajime
AU - Tsuneyoshi, Masazumi
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Background: Sarcomatous hepatocellular carcinoma (HCC) has a worse prognosis than ordinary HCC. The relationship between the malignant potential of sarcomatous HCC and cell proliferation or cell adhesion is unknown. This study was undertaken to clarify this relationship. Methods: In 21 cases of sarcomatous HCC, including 16 surgically resected and five autopsy cases, immunohistochemistry was used to compare the sarcomatous component (s-comp) and the ordinary component (o-comp) within each sarcomatous HCC. Results: We found 15 epithelial-cadherin (E-cadherin)-positive cases in o-comp (79%) and nine positive cases in s-comp (43%). The difference between sarcomatous HCC and ordinary HCC in E-cadherin-positive tumor prevalence was significant (P<0.05). The Ki-67 (MIB1) labeling index ratio was 127±40 in s-comp and 80±33 in o-comp, and there was a greater tendency to have an ability to multiply in s-comp than in o-comp (P=0.096). Conclusion: This study indicated that the loss of E-cadherin related to a morphological alteration in sarcomatous HCC; however, no relationship in respect to the malignant potential was found.
AB - Background: Sarcomatous hepatocellular carcinoma (HCC) has a worse prognosis than ordinary HCC. The relationship between the malignant potential of sarcomatous HCC and cell proliferation or cell adhesion is unknown. This study was undertaken to clarify this relationship. Methods: In 21 cases of sarcomatous HCC, including 16 surgically resected and five autopsy cases, immunohistochemistry was used to compare the sarcomatous component (s-comp) and the ordinary component (o-comp) within each sarcomatous HCC. Results: We found 15 epithelial-cadherin (E-cadherin)-positive cases in o-comp (79%) and nine positive cases in s-comp (43%). The difference between sarcomatous HCC and ordinary HCC in E-cadherin-positive tumor prevalence was significant (P<0.05). The Ki-67 (MIB1) labeling index ratio was 127±40 in s-comp and 80±33 in o-comp, and there was a greater tendency to have an ability to multiply in s-comp than in o-comp (P=0.096). Conclusion: This study indicated that the loss of E-cadherin related to a morphological alteration in sarcomatous HCC; however, no relationship in respect to the malignant potential was found.
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U2 - 10.1046/j.1440-1746.2003.02888.x
DO - 10.1046/j.1440-1746.2003.02888.x
M3 - Article
C2 - 12653890
AN - SCOPUS:0038218491
VL - 18
SP - 415
EP - 423
JO - Journal of Gastroenterology and Hepatology (Australia)
JF - Journal of Gastroenterology and Hepatology (Australia)
SN - 0815-9319
IS - 4
ER -