Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy. Results From Multicenter Registration in Japan.

Takashi Fujita, Noboru Fujino, Ryuichiro Anan, Chuwa Tei, Toru Kubo, Yoshinori Doi, Shintaro Kinugawa, Hiroyuki Tsutsui, Shigeki Kobayashi, Masafumi Yano, Masanori Asakura, Masafumi Kitakaze, Issei Komuro, Tetsuo Konno, Kenshi Hayashi, Masa aki Kawashiri, Hidekazu Ino, Masakazu Yamagishi

Research output: Contribution to journalArticle

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Abstract

Objectives: This study investigated the occurrence of cardiovascular events in patients with hypertensive heart disease (HHD) or hypertrophic cardiomyopathy (HCM) with or without sarcomere gene mutations. Background: Although HHD and HCM are associated with left ventricular hypertrophy (LVH), few data exist regarding the difference in prognosis between them. Methods: We enrolled 256 patients with LVH (>13 mm) screened for sarcomere gene mutations. We divided them into 3 groups: the first had HHD without sarcomere gene mutations (group H), the second had sarcomere gene mutations (group G), and the third had neither sarcomere gene mutations nor HHD (group NG). We compared the occurrence of sudden cardiac death, ventricular tachycardia/fibrillation, admission for heart failure, and atrial fibrillation for 1 year. Results: Group G (n= 78, 36 men; mean age, 53.4 years) experienced more total cardiovascular events than group H (n=45, 32 men; mean age, 67.4 years) (p= 0.042) after adjustments for age and sex, although there was no significant difference in total cardiovascular events between groups H and NG (n= 98, 66 men; mean age, 62.0 years). With Kaplan-Meier analysis, group G exhibited a significantly higher incidence of admission for heart failure (p= 0.017) and atrial fibrillation (p= 0.045) than group H in those 50 years of age and older. Additionally, there was a significant difference in total cardiovascular events between groups G and NG (p= 0.021). Conclusions: These results demonstrate that HCM with sarcomere gene mutations can be associated with increased cardiovascular events compared with HHD or HCM without sarcomere gene mutations.

Original languageEnglish
Pages (from-to)459-466
Number of pages8
JournalJACC: Heart Failure
Volume1
Issue number6
DOIs
Publication statusPublished - Dec 1 2013

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Sarcomeres
Left Ventricular Hypertrophy
Japan
Hypertrophic Cardiomyopathy
Mutation
Heart Diseases
Genes
Atrial Fibrillation
Heart Failure
Sudden Cardiac Death
Kaplan-Meier Estimate
Ventricular Fibrillation
Ventricular Tachycardia
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy. Results From Multicenter Registration in Japan. / Fujita, Takashi; Fujino, Noboru; Anan, Ryuichiro; Tei, Chuwa; Kubo, Toru; Doi, Yoshinori; Kinugawa, Shintaro; Tsutsui, Hiroyuki; Kobayashi, Shigeki; Yano, Masafumi; Asakura, Masanori; Kitakaze, Masafumi; Komuro, Issei; Konno, Tetsuo; Hayashi, Kenshi; Kawashiri, Masa aki; Ino, Hidekazu; Yamagishi, Masakazu.

In: JACC: Heart Failure, Vol. 1, No. 6, 01.12.2013, p. 459-466.

Research output: Contribution to journalArticle

Fujita, T, Fujino, N, Anan, R, Tei, C, Kubo, T, Doi, Y, Kinugawa, S, Tsutsui, H, Kobayashi, S, Yano, M, Asakura, M, Kitakaze, M, Komuro, I, Konno, T, Hayashi, K, Kawashiri, MA, Ino, H & Yamagishi, M 2013, 'Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy. Results From Multicenter Registration in Japan.', JACC: Heart Failure, vol. 1, no. 6, pp. 459-466. https://doi.org/10.1016/j.jchf.2013.08.007
Fujita, Takashi ; Fujino, Noboru ; Anan, Ryuichiro ; Tei, Chuwa ; Kubo, Toru ; Doi, Yoshinori ; Kinugawa, Shintaro ; Tsutsui, Hiroyuki ; Kobayashi, Shigeki ; Yano, Masafumi ; Asakura, Masanori ; Kitakaze, Masafumi ; Komuro, Issei ; Konno, Tetsuo ; Hayashi, Kenshi ; Kawashiri, Masa aki ; Ino, Hidekazu ; Yamagishi, Masakazu. / Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy. Results From Multicenter Registration in Japan. In: JACC: Heart Failure. 2013 ; Vol. 1, No. 6. pp. 459-466.
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title = "Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy. Results From Multicenter Registration in Japan.",
abstract = "Objectives: This study investigated the occurrence of cardiovascular events in patients with hypertensive heart disease (HHD) or hypertrophic cardiomyopathy (HCM) with or without sarcomere gene mutations. Background: Although HHD and HCM are associated with left ventricular hypertrophy (LVH), few data exist regarding the difference in prognosis between them. Methods: We enrolled 256 patients with LVH (>13 mm) screened for sarcomere gene mutations. We divided them into 3 groups: the first had HHD without sarcomere gene mutations (group H), the second had sarcomere gene mutations (group G), and the third had neither sarcomere gene mutations nor HHD (group NG). We compared the occurrence of sudden cardiac death, ventricular tachycardia/fibrillation, admission for heart failure, and atrial fibrillation for 1 year. Results: Group G (n= 78, 36 men; mean age, 53.4 years) experienced more total cardiovascular events than group H (n=45, 32 men; mean age, 67.4 years) (p= 0.042) after adjustments for age and sex, although there was no significant difference in total cardiovascular events between groups H and NG (n= 98, 66 men; mean age, 62.0 years). With Kaplan-Meier analysis, group G exhibited a significantly higher incidence of admission for heart failure (p= 0.017) and atrial fibrillation (p= 0.045) than group H in those 50 years of age and older. Additionally, there was a significant difference in total cardiovascular events between groups G and NG (p= 0.021). Conclusions: These results demonstrate that HCM with sarcomere gene mutations can be associated with increased cardiovascular events compared with HHD or HCM without sarcomere gene mutations.",
author = "Takashi Fujita and Noboru Fujino and Ryuichiro Anan and Chuwa Tei and Toru Kubo and Yoshinori Doi and Shintaro Kinugawa and Hiroyuki Tsutsui and Shigeki Kobayashi and Masafumi Yano and Masanori Asakura and Masafumi Kitakaze and Issei Komuro and Tetsuo Konno and Kenshi Hayashi and Kawashiri, {Masa aki} and Hidekazu Ino and Masakazu Yamagishi",
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T1 - Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy. Results From Multicenter Registration in Japan.

AU - Fujita, Takashi

AU - Fujino, Noboru

AU - Anan, Ryuichiro

AU - Tei, Chuwa

AU - Kubo, Toru

AU - Doi, Yoshinori

AU - Kinugawa, Shintaro

AU - Tsutsui, Hiroyuki

AU - Kobayashi, Shigeki

AU - Yano, Masafumi

AU - Asakura, Masanori

AU - Kitakaze, Masafumi

AU - Komuro, Issei

AU - Konno, Tetsuo

AU - Hayashi, Kenshi

AU - Kawashiri, Masa aki

AU - Ino, Hidekazu

AU - Yamagishi, Masakazu

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Objectives: This study investigated the occurrence of cardiovascular events in patients with hypertensive heart disease (HHD) or hypertrophic cardiomyopathy (HCM) with or without sarcomere gene mutations. Background: Although HHD and HCM are associated with left ventricular hypertrophy (LVH), few data exist regarding the difference in prognosis between them. Methods: We enrolled 256 patients with LVH (>13 mm) screened for sarcomere gene mutations. We divided them into 3 groups: the first had HHD without sarcomere gene mutations (group H), the second had sarcomere gene mutations (group G), and the third had neither sarcomere gene mutations nor HHD (group NG). We compared the occurrence of sudden cardiac death, ventricular tachycardia/fibrillation, admission for heart failure, and atrial fibrillation for 1 year. Results: Group G (n= 78, 36 men; mean age, 53.4 years) experienced more total cardiovascular events than group H (n=45, 32 men; mean age, 67.4 years) (p= 0.042) after adjustments for age and sex, although there was no significant difference in total cardiovascular events between groups H and NG (n= 98, 66 men; mean age, 62.0 years). With Kaplan-Meier analysis, group G exhibited a significantly higher incidence of admission for heart failure (p= 0.017) and atrial fibrillation (p= 0.045) than group H in those 50 years of age and older. Additionally, there was a significant difference in total cardiovascular events between groups G and NG (p= 0.021). Conclusions: These results demonstrate that HCM with sarcomere gene mutations can be associated with increased cardiovascular events compared with HHD or HCM without sarcomere gene mutations.

AB - Objectives: This study investigated the occurrence of cardiovascular events in patients with hypertensive heart disease (HHD) or hypertrophic cardiomyopathy (HCM) with or without sarcomere gene mutations. Background: Although HHD and HCM are associated with left ventricular hypertrophy (LVH), few data exist regarding the difference in prognosis between them. Methods: We enrolled 256 patients with LVH (>13 mm) screened for sarcomere gene mutations. We divided them into 3 groups: the first had HHD without sarcomere gene mutations (group H), the second had sarcomere gene mutations (group G), and the third had neither sarcomere gene mutations nor HHD (group NG). We compared the occurrence of sudden cardiac death, ventricular tachycardia/fibrillation, admission for heart failure, and atrial fibrillation for 1 year. Results: Group G (n= 78, 36 men; mean age, 53.4 years) experienced more total cardiovascular events than group H (n=45, 32 men; mean age, 67.4 years) (p= 0.042) after adjustments for age and sex, although there was no significant difference in total cardiovascular events between groups H and NG (n= 98, 66 men; mean age, 62.0 years). With Kaplan-Meier analysis, group G exhibited a significantly higher incidence of admission for heart failure (p= 0.017) and atrial fibrillation (p= 0.045) than group H in those 50 years of age and older. Additionally, there was a significant difference in total cardiovascular events between groups G and NG (p= 0.021). Conclusions: These results demonstrate that HCM with sarcomere gene mutations can be associated with increased cardiovascular events compared with HHD or HCM without sarcomere gene mutations.

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