Sarcopenia is associated with incident albuminuria in patients with type 2 diabetes: A retrospective observational study

Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Isao Minami, Takanobu Yoshimoto, Yoshihiro Ogawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Sarcopenia, defined as age-related loss of skeletal muscle mass and function, increases the risk of albuminuria. However, it has still unknown whether sarcopenia could increase the risk for the progression of albuminuria. A total 238 patients with type 2 diabetes (mean age 64 ± 12 years; 39.2% women) were studied in the present retrospective observational study. The prevalence of sarcopenia was 17.6%. During the median follow-up period of 2.6 years, albuminuria was measured 5.8 ± 1.8 times, and progression of albuminuria was observed in 14.9% of patients with normoalbuminuria, as was 11.5% in those with microalbuminuria. Sarcopenia was significantly associated with both progression (hazard ratio 2.61, 95% confidence interval 1.08–6.31, P = 0.034) and regression (hazard ratio 0.23, 95% confidence interval 0.05–0.98, P = 0.048) of albuminuria by multivariate Cox regression analysis. The present data suggest that sarcopenia is an important determinant of both progression and regression of albuminuria in patients with type 2 diabetes.

Original languageEnglish
Pages (from-to)783-787
Number of pages5
JournalJournal of Diabetes Investigation
Volume8
Issue number6
DOIs
Publication statusPublished - Nov 2017

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Sarcopenia
Albuminuria
Type 2 Diabetes Mellitus
Observational Studies
Retrospective Studies
Confidence Intervals
Skeletal Muscle
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Sarcopenia is associated with incident albuminuria in patients with type 2 diabetes : A retrospective observational study. / Bouchi, Ryotaro; Fukuda, Tatsuya; Takeuchi, Takato; Minami, Isao; Yoshimoto, Takanobu; Ogawa, Yoshihiro.

In: Journal of Diabetes Investigation, Vol. 8, No. 6, 11.2017, p. 783-787.

Research output: Contribution to journalArticle

Bouchi, Ryotaro ; Fukuda, Tatsuya ; Takeuchi, Takato ; Minami, Isao ; Yoshimoto, Takanobu ; Ogawa, Yoshihiro. / Sarcopenia is associated with incident albuminuria in patients with type 2 diabetes : A retrospective observational study. In: Journal of Diabetes Investigation. 2017 ; Vol. 8, No. 6. pp. 783-787.
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