Scale-free dynamics of somatic adaptability in immune system

Shiro Saito, Osamu Narikiyo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The long-time dynamics of somatic adaptability in immune system is simulated by a simple physical model defined in the shape space. The immune system described by the model exhibits a scale free behavior as is observed in living systems. The balance between the positive and negative feedbacks of the model leads to a robust immune system where the positive one corresponds to the formation of memory cells and the negative one to immunosuppression. Also the immunosenescence of the system is discussed based on the time-dependence of the epigenetic landscape of the adaptive immune cells in the shape space.

Original languageEnglish
Pages (from-to)420-424
Number of pages5
JournalBioSystems
Volume103
Issue number3
DOIs
Publication statusPublished - Mar 1 2011

Fingerprint

Immune system
Immune System
Adaptability
Shape Space
Feedback
Living Systems
Positive Feedback
Negative Feedback
Cell Shape
Cell
Time Dependence
Physical Model
Epigenomics
Immunosuppression
Data storage equipment
Model

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Mathematics

Cite this

Scale-free dynamics of somatic adaptability in immune system. / Saito, Shiro; Narikiyo, Osamu.

In: BioSystems, Vol. 103, No. 3, 01.03.2011, p. 420-424.

Research output: Contribution to journalArticle

Saito, Shiro ; Narikiyo, Osamu. / Scale-free dynamics of somatic adaptability in immune system. In: BioSystems. 2011 ; Vol. 103, No. 3. pp. 420-424.
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