Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo

Jun Ichi Oyama, Shinji Satoh, Nobuhiro Suematsu, Toshiaki Kadokami, Toyoki Maeda, Masahiro Sugano, Naoki Makino

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effect of a novel free radical scavenger, edaravone, on coronary endothelial dysfunction was examined in patients who had no significant stenosis of coronary arteries, to elucidate the role of free radicals on coronary endothelial dysfunction. The coronary blood flow (CBF) responses to acetylcholine (ACh) were measured by quantitative coronary arteriography and the intracoronary Doppler technique before and after the administration of edaravone. Twenty-four patients were divided into two groups on the basis of CBF responses to ACh; those with "attenuated" (%Δ CBF < 300%, n = 12) and "normal" (%Δ CBF > 300%, n = 12) flow responses. An intracoronary infusion of edaravone significantly improved ACh-induced increases in CBF in patients with attenuated flow responses; however, edaravone had no effect in those with normal flow responses (36.8% ± 7.3% vs 0.0% ± 5.1%, P < 0.01). The plasma levels of nitric oxide compounds (NOx) in the attenuated response group were lower than those in the normal group (35.7 ± 2.3 vs 49.4 ± 6.2 μM, P < 0.01) and correlated with the magnitude of CBF improvement by edaravone (r = 0.566, P < 0.01). The plasma level of malondialdehyde and 4-hydroxynonenal, which indicates the level of oxidative stress, in the attenuated group was higher than that in the normal group (6.9 ± 0.9 vs 3.3 ± 0.5 μM, P < 0.01) and correlated with the magnitude of CBF improvement by edaravone (r = 0.854, P < 0.01). A free radical scavenger improved the ACh-induced CBF response in patients with coronary atherosclerosis in vivo. Therefore, the current results suggest that scavenging free radicals has a beneficial effect for patients with coronary endothelial dysfunction.

Original languageEnglish
Pages (from-to)379-385
Number of pages7
JournalHeart and Vessels
Volume25
Issue number5
DOIs
Publication statusPublished - Sep 1 2010

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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