TY - JOUR
T1 - SCH23390, a dopamine D1 receptor antagonist, suppressed scratching behavior induced by compound 48/80 in mice
AU - Akimoto, Yoriko
AU - Furuse, Mitsuhiro
N1 - Funding Information:
This work was supported by a Research Fellowship of the Japan Society for the Promotion of Science for Young Scientists (No. 212970 ).
PY - 2011/11/16
Y1 - 2011/11/16
N2 - To clarify the mechanisms by which compound 48/80 (C48/80) induces scratching behavior, the involvement of dopamine D1 receptors was investigated. The intracisternal (i.t.) administration of SCH23390 (1.0 μg), a selective dopamine D1 receptor antagonist, significantly decreased C48/80-induced scratching behavior in mice. These results suggest that dopamine D1 receptors contribute to scratching behavior or the itch sensation induced by subcutaneous injection of C48/80 in mice. Co-administration of SCH23390 and C48/80 enhanced c-fos immunoreactivities in the peduncular part of the lateral hypothalamus (PLH), whereas the immunoreactivities in the other groups were unchanged. The dopaminergic system may be playing an important role in the suppression of C48/80-induced scratching behavior by SCH23390.
AB - To clarify the mechanisms by which compound 48/80 (C48/80) induces scratching behavior, the involvement of dopamine D1 receptors was investigated. The intracisternal (i.t.) administration of SCH23390 (1.0 μg), a selective dopamine D1 receptor antagonist, significantly decreased C48/80-induced scratching behavior in mice. These results suggest that dopamine D1 receptors contribute to scratching behavior or the itch sensation induced by subcutaneous injection of C48/80 in mice. Co-administration of SCH23390 and C48/80 enhanced c-fos immunoreactivities in the peduncular part of the lateral hypothalamus (PLH), whereas the immunoreactivities in the other groups were unchanged. The dopaminergic system may be playing an important role in the suppression of C48/80-induced scratching behavior by SCH23390.
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U2 - 10.1016/j.ejphar.2011.09.011
DO - 10.1016/j.ejphar.2011.09.011
M3 - Article
C2 - 21946101
AN - SCOPUS:80054744473
VL - 670
SP - 162
EP - 167
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -