Schizandrin reverses memory impairment in rats

Nobuaki Egashira, Kouji Kurauchi, Katsunori Iwasaki, Kenichi Mishima, Kensuke Orito, Ryozo Oishi, Michihiro Fujiwara

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The present study investigated the effect of schizandrin, a component of the fruit of Schizandra chinesis Baill (Fructus Schizandrae), on memory impairment in rats. Scopolamine (0.5 mg/kg, i.p.), a non-selective muscarinic receptor antagonist, markedly impaired spatial memory in an eight-arm radial maze. A higher dose of scopolamine (3 mg/kg, i.p.) also impaired the passive avoidance response. Schizandrin (1 and 10 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of spatial memory. Similarly, schizandrin (1 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of the passive avoidance response. Moreover, in mice, schizandrin (1 and 10 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M1 receptor agonist. Taken together these findings suggest that schizandrin reverses scopolamine-induced memory impairment, in part, by enhancing cholinergic function, and that schizandrin might be useful for treating memory deficits.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalPhytotherapy Research
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 2008

All Science Journal Classification (ASJC) codes

  • Pharmacology

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    Egashira, N., Kurauchi, K., Iwasaki, K., Mishima, K., Orito, K., Oishi, R., & Fujiwara, M. (2008). Schizandrin reverses memory impairment in rats. Phytotherapy Research, 22(1), 49-52. https://doi.org/10.1002/ptr.2258