Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier

Teruaki Hasegawa, Tomohisa Fujisawa, Shuichi Haraguchi, Munenori Numata, Ryouji Karinaga, Taro Kimura, Shiro Okumura, Kazuo Sakurai, Seiji Shinkai

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Schizophyllan having folate-appendages was synthesized from native schizophyllan through NaIO 4-oxidation and the subsequent reductive amination in aqueous ammonia followed by amido-coupling with folic acid. The resulting folate-appended schizophyllan can form stable complex with poly(dA), show specific affinity toward folate binding protein, and mediate effective antisense activity in cancer cells.

Original languageEnglish
Pages (from-to)327-330
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number2
DOIs
Publication statusPublished - Jan 17 2005

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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