TY - JOUR
T1 - Schizophyllum commune sinusitis after allogeneic bone marrow transplantation for myelodysplastic syndrome
T2 - A case report and literature review
AU - Narazaki, Taisuke
AU - Nakashima, Yasuhiro
AU - Tsukamoto, Yasuhiro
AU - Nishida, Ruriko
AU - Tsuda, Mariko
AU - Muta, Hiroki
AU - Kimura, Daisaku
AU - Masuda, Toru
AU - Takamatsu, Akiko
AU - Kohashi, Kenichi
AU - Murakami, Daisuke
AU - Shiratsuchi, Motoaki
AU - Ogawa, Yoshihiro
N1 - Publisher Copyright:
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Sinusitis is a serious infectious complication of allogeneic hematopoietic stem cell transplantation. Schizophyllum commune (S commune) is a common basidiomycete fungus that is rarely involved in human disease. We report herein a case of S commune sinusitis after allogeneic bone marrow transplantation. A 66-year-old man with myelodysplastic syndrome underwent allogeneic bone marrow transplantation and developed maxillary and ethmoid sinusitis. The sinusitis did not improve with liposomal amphotericin B after neutrophil engraftment, so we considered that surgical intervention was needed for the recovery of sinusitis. Endoscopic sinus surgery was performed. In the debridement tissue of paranasal mucosa, filamentous fungal elements were observed. Moreover, genetic analysis of the tissue revealed the presence of S commune. Schizophyllum commune should be recognized as a fungal pathogen that causes sinusitis after allogeneic hematopoietic stem cell transplantation. This case suggests the effectiveness of prompt surgical intervention with liposomal amphotericin B treatment for S commune sinusitis and the usefulness of genetic diagnosis for cases under antifungal treatment. (160 words).
AB - Sinusitis is a serious infectious complication of allogeneic hematopoietic stem cell transplantation. Schizophyllum commune (S commune) is a common basidiomycete fungus that is rarely involved in human disease. We report herein a case of S commune sinusitis after allogeneic bone marrow transplantation. A 66-year-old man with myelodysplastic syndrome underwent allogeneic bone marrow transplantation and developed maxillary and ethmoid sinusitis. The sinusitis did not improve with liposomal amphotericin B after neutrophil engraftment, so we considered that surgical intervention was needed for the recovery of sinusitis. Endoscopic sinus surgery was performed. In the debridement tissue of paranasal mucosa, filamentous fungal elements were observed. Moreover, genetic analysis of the tissue revealed the presence of S commune. Schizophyllum commune should be recognized as a fungal pathogen that causes sinusitis after allogeneic hematopoietic stem cell transplantation. This case suggests the effectiveness of prompt surgical intervention with liposomal amphotericin B treatment for S commune sinusitis and the usefulness of genetic diagnosis for cases under antifungal treatment. (160 words).
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U2 - 10.1111/tid.13205
DO - 10.1111/tid.13205
M3 - Article
C2 - 31674700
AN - SCOPUS:85075071930
SN - 1398-2273
VL - 22
JO - Transplant Infectious Disease
JF - Transplant Infectious Disease
IS - 1
M1 - e13205
ER -
