Sclerosing stromal tumor of the ovary

A clinicopathologic, immunohistochemical, ultrastructural, and cytogenetic analysis with special reference to its vasculature

Shigeto Kawauchi, Takahiro Tsuji, Tsunehisa Kaku, Toshiharu Kamura, Hitoo Nakano, Masazumi Tsuneyoshi

Research output: Contribution to journalArticle

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Abstract

Sclerosing stromal tumor (SST) is a rare ovarian neoplasm occurring predominantly in young women and is histologically characterized by cellular heterogeneity, prominent vasculature, and a pseudolobular appearance composed of cellular and hypocellular areas. In the current study, three cases of SST were ultrastructurally examined and the tumors were found to be composed of several kinds of cells, i.e., luteinized thecalike cells, spindle-shaped fibroblastic cells, and primitive mesenchymal cells. These findings thus supported the ovarian stromal origin of SST. Twelve cases of SST also were analyzed immunohistochemically and demonstrated an expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) in the luteinized thecalike cells and its receptor, fms-like tyrosine kinase 1 (flt- 1), in capillary to medium-sized blood vessels. Reverse transcription- polymerase chain reaction (RT-PCR) also showed an expression of VPF/VEGF messenger RNA in SSTs. Accordingly, the characteristic vasculature and edema of SSTs were considered to be associated with the expression of VPF/VEGF. In addition, a fluorescence in situ hybridization (FISH) analysis also showed cells with three copy number of chromosome 12 in 13-21% of all examined SST cells, which suggested the presence of chromosome 12 trisomy in SSTs as well as in other ovarian stromal tumors.

Original languageEnglish
Pages (from-to)83-92
Number of pages10
JournalAmerican Journal of Surgical Pathology
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 12 1998

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Cytogenetic Analysis
Ovary
Vascular Endothelial Growth Factor A
Neoplasms
Chromosomes, Human, Pair 12
Vascular Endothelial Growth Factor Receptor-1
Trisomy
Stromal Cells
Fluorescence In Situ Hybridization
Ovarian Neoplasms
Reverse Transcription
Blood Vessels
Edema
Polymerase Chain Reaction
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Sclerosing stromal tumor of the ovary : A clinicopathologic, immunohistochemical, ultrastructural, and cytogenetic analysis with special reference to its vasculature. / Kawauchi, Shigeto; Tsuji, Takahiro; Kaku, Tsunehisa; Kamura, Toshiharu; Nakano, Hitoo; Tsuneyoshi, Masazumi.

In: American Journal of Surgical Pathology, Vol. 22, No. 1, 12.01.1998, p. 83-92.

Research output: Contribution to journalArticle

Kawauchi, Shigeto ; Tsuji, Takahiro ; Kaku, Tsunehisa ; Kamura, Toshiharu ; Nakano, Hitoo ; Tsuneyoshi, Masazumi. / Sclerosing stromal tumor of the ovary : A clinicopathologic, immunohistochemical, ultrastructural, and cytogenetic analysis with special reference to its vasculature. In: American Journal of Surgical Pathology. 1998 ; Vol. 22, No. 1. pp. 83-92.
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