Scopoletin: An inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei

Tai Hyun Kang, Hyun Ock Pae, Sei Joon Jeong, Ji Chang Yoo, Byung Min Choi, Chang Duk Jun, Hun Taeg Chung, Tomofumi Miyamoto, R. Higuchi, Youn Chul Kim

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Bioassay-guided fractionation of an H2O extract of Artemisia feddei has furnished an inducible nitric oxide synthase (iNOS) inhibitory coumarin, scopoletin (1) and one of the inactive sesquiterpenes, achillin (2). Compound 1 showed inhibition of nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-γ (IFN- γ) plus lipopolysaccharide (LPS). The inhibition of NO synthesis of 1 was due to suppression of iNOS mRNA and iNOS protein, as determined by Northern and Western blotting, respectively.

Original languageEnglish
Pages (from-to)400-403
Number of pages4
JournalPlanta medica
Volume65
Issue number5
DOIs
Publication statusPublished - Jul 8 1999

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Kang, T. H., Pae, H. O., Jeong, S. J., Yoo, J. C., Choi, B. M., Jun, C. D., Chung, H. T., Miyamoto, T., Higuchi, R., & Kim, Y. C. (1999). Scopoletin: An inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei. Planta medica, 65(5), 400-403. https://doi.org/10.1055/s-1999-14014