Screening of a glycopolymer library for GM1 mimetics synthesized by the “carbohydrate module method”

Masanori Nagao, Takeshi Uemura, Tasuku Horiuchi, Yu Hoshino, Yoshiko Miura

Research output: Contribution to journalArticlepeer-review

Abstract

The “carbohydrate module method” is a promising approach for oligosaccharide mimetics using polymeric materials. However, it is difficult to predict the optimal structure for a particular oligosaccharide mimetic, and an efficient strategy for the synthesis and evaluation of glycopolymers is desirable. In this study, a screening of glycopolymers for the “carbohydrate module method” by a combination of photoinduced electron/energy transfer-reversible addition-fragmentation chain-transfer (PET-RAFT) polymerization and surface plasmon resonance imaging (SPRI) is demonstrated. The facile and fast screening of synthetic glycomimetics was achieved, and the glycopolymer with the optimal structure as a GM1 mimetic strongly interacted with the cholera toxin B subunit.

Original languageEnglish
Pages (from-to)10871-10874
Number of pages4
JournalChemical Communications
Volume57
Issue number83
DOIs
Publication statusPublished - Oct 25 2021

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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